Conopharyngine is the major

alkaloid Alkaloids are a class of basic BASIC (Beginners' All-purpose Symbolic Instruction Code) is a family of general-purpose, high-level programming languages designed for ease of use. The original version was created by John G. Kemeny and Th ...

present in the leaves and stem-bark of '' Tabernaemontana pachysiphon'' and '' Conopharyngia durissima''. It is closely related voacangine and coronaridine. Conopharyngine pseudoindoxyl, a derivative of it, is also found in the same plant ''Tabernaemontana pachysiphon''.

Pharmacology

It possess central nervous system stimulant activity and produces

bradycardia Bradycardia (also sinus bradycardia) is a slow resting heart rate, commonly under 60 beats per minute (BPM) as determined by an electrocardiogram. It is considered to be a normal heart rate during sleep, in young and healthy or elderly adults, ...

and

hypotension Hypotension is low blood pressure. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Blood pressure is indicated by two numbers, the systolic blood pressure (the top number) and the dia ...

in cats. It has weak

acetylcholinesterase Acetylcholinesterase (HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme that catalyzes the breakdown of acety ...

inhibitory activity and significantly increases

hexobarbitone Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia for su ...

induced sleeping time.

Toxicity

It has low

intravenous toxicity Intravenous therapy (abbreviated as IV therapy) is a medical technique that administers fluids, medications and nutrients directly into a person's vein. The intravenous route of administration is commonly used for rehydration or to provide nutrie ...

in mice (LD₅₀ = 143 mg/kg).

References

Alkaloids found in Iboga Methoxy compounds Heterocyclic compounds with 5 rings Methyl esters Nitrogen heterocycles Tryptamine alkaloids {{Alkaloid-stub

Pharmacology

Toxicity

See also

References