The component detection algorithm (CODA) is a name for a type of LC-MS and

chemometrics Chemometrics is the science of extracting information from chemical systems by data-driven means. Chemometrics is inherently interdisciplinary, using methods frequently employed in core data-analytic disciplines such as multivariate statistics, ...

Chemometric analysis of complex hyphenated data: Improvements of the component detection algorithm. W. Windig and W.F. Smith, Journal of Chromatography A, Volume 1158, Issues 1-2, 27 July 2007, Pages 251-257
software algorithm focused on detecting peaks in noisy

chromatogram In chemical analysis, chromatography is a laboratory technique for the Separation process, separation of a mixture into its components. The mixture is dissolved in a fluid solvent (gas or liquid) called the ''mobile phase'', which carries it ...

s (TIC) often obtained using the

electrospray ionization Electrospray ionization (ESI) is a technique used in mass spectrometry to produce ions using an electrospray in which a high voltage is applied to a liquid to create an aerosol. It is especially useful in producing ions from macromolecules becau ...

technique. The implementation of the algorithm from one piece of

mass spectrometry Mass spectrometry (MS) is an analytical technique that is used to measure the mass-to-charge ratio of ions. The results are presented as a '' mass spectrum'', a plot of intensity as a function of the mass-to-charge ratio. Mass spectrometry is u ...

software to another differs. Some implementations need clean chromatograms to substruct background.

References

Computational chemistry {{computer-chemistry-stub