Competing endogenous RNAs (

ceRNA Cerna may refer to: Populated places * Cerna, Croatia, Vukovar-Syrmia County, Croatia * Černá (Žďár nad Sázavou District), Czech Republic * Černá, Semily District, Czech Republic * Cerna, Tulcea, Romania * A village in Vaideeni Commune, ...

s, also refer as miRNA sponges) hypothesis:

s regulate other

RNA transcript Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules calle ...

s (e.g., PTEN) by competing for shared

microRNA MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. m ...

s. They are playing important roles in developmental,

physiological Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemica ...

and

pathological Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in t ...

processes, such as

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bl ...

. Multiple classes of ncRNAs (lncRNAs, circRNAs, pseudogenes) and

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

-coding mRNAs function as key

s (sponges) and to regulate the expression of mRNAs in

plant Plants are predominantly Photosynthesis, photosynthetic eukaryotes of the Kingdom (biology), kingdom Plantae. Historically, the plant kingdom encompassed all living things that were not animals, and included algae and fungi; however, all curr ...

s and mammalian cells. This competing endogenous RNA (ceRNA) databases and resources is a compilation of databases and web portals and servers used for ceRNA prediction and ceRNA networks.

References

* {{DEFAULTSORT:MicroRNA RNA MicroRNA Genetics databases zh:CeRNA资源及数据库