The collagen gel contraction assay is an

in vitro ''In vitro'' (meaning ''in glass'', or ''in the glass'') Research, studies are performed with Cell (biology), cells or biological molecules outside their normal biological context. Colloquially called "test-tube experiments", these studies in ...

model of

wound contraction Wound contracture is a process that may occur during wound healing when an excess of Wound healing#Contraction, wound contraction, a normal healing process, leads to physical deformity characterized by skin constriction and functional limitations. ...

. It is performed using the dermal equivalent model, which consists of

dermal fibroblast Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts ge ...

s seeded into a

collagen Collagen () is the main structural protein in the extracellular matrix of the connective tissues of many animals. It is the most abundant protein in mammals, making up 25% to 35% of protein content. Amino acids are bound together to form a trip ...

gel.

References

Skin physiology {{med-stub