Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study
rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects synovial joint, joints. It typically results in warm, swollen, and painful joints. Pain and stiffness often worsen following rest. Most commonly, the wrist and h ...
.
CIA is induced in mice by injecting them with an emulsion of
complete Freund's adjuvant and
type II collagen
Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by homotrimers of collagen, type II, alpha 1 chains.
It makes up 50% of all protein in cartilage and 85–90% of collagen o ...
.
In rats, only one injection is needed, but mice are normally injected twice.
[ Arthritis in mice induced by a single immunisation with collagen ]
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References
Further reading
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External links
Animal testing
Arthritis
Collagens
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