Collaborative Drug Discovery (CDD) is a software company founded in 2004 as a spin-out of

Eli Lilly Eli Lilly (July 8, 1838 – June 6, 1898) was an American soldier, pharmacist, chemist, and businessman who founded the Eli Lilly and Company pharmaceutical corporation. Lilly enlisted in the Union Army during the American Civil War and r ...

by Barry Bunin, PhD. CDD utilizes a

web-based A web application (or web app) is application software that is accessed using a web browser. Web applications are delivered on the World Wide Web to users with an active network connection. History In earlier computing models like client-serve ...

database solution for managing

drug discovery In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by ...

data, primarily through the CDD Vault product which is focused around small molecules and associated bio-assay data. In 2021, CDD launched its first commercial data offering, PharmaKB, formerly BioHarmony, as The Pharma KnowledgeBase, which is centered around pharma company, drug, and disease information for research, business intelligence, and investors.

Products

1. CDD Vault is a research informatics

web platform The Web platform is a collection of technologies developed as open standards by the World Wide Web Consortium and other standardization bodies such as the Web Hypertext Application Technology Working Group, the Unicode Consortium, the Internet Engi ...

by Collaborative Drug Discovery. It contains several modules for collaborative project teams to manage, analyze, and share both private & public data. It is used by biotech companies, CROs, academic labs, research hospitals, agrochemical and consumer goods companies. CDD Vault is a modern web application for chemical registration, assay data management, and SAR analysis. It is designed to be simple to use and extremely secure. 2. PharmaKB is a

knowledgebase A knowledge base (KB) is a technology used to store complex structured and unstructured information used by a computer system. The initial use of the term was in connection with expert systems, which were the first knowledge-based systems. Or ...

for pharma-related information. Available data spans (

preclinical In drug development, preclinical development, also termed preclinical studies or nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug ...

clinical Clinical may refer to: Healthcare * Of or about a clinic, a healthcare facility * Of or about the practice of medicine Other uses * ''Clinical'' (film), a 2017 American horror thriller See also * * * Clinical chemistry, the analysis of bodily flu ...

, financial, patents, and post-approval) information about companies, drugs, and diseases. It is designed to be used by researchers, those practicing

business intelligence Business intelligence (BI) comprises the strategies and technologies used by enterprises for the data analysis and management of business information. Common functions of business intelligence technologies include reporting, online analytical pr ...

, and investors. PharmaKB also offers real-time updates with a subscription model instead of static reports. As a throwback to CDD Vault's slogan of "Complexity Simplified", PharmaKB uses the slogan of "Data Simplified" and promotes a data trilogy of Company, Drug, and Disease. The product is meant to expand the company's scope from working with mostly preclinical researchers to being relevant for clinical and post-approval stages of

drug development Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. It includes preclinical research on microorganisms and animals, filing for r ...

, including:

Pharmacovigilance Term Given By Tushar Sharma (UPES Batch 2025) Pharmacovigilance (PV, or PhV), also known as drug safety, is the pharmaceutical science relating to the "collection, detection, assessment, monitoring, and prevention" of adverse effects with phar ...

Drug Safety Term Given By Tushar Sharma (UPES Batch 2025) Pharmacovigilance (PV, or PhV), also known as drug safety, is the pharmaceutical science relating to the "collection, detection, assessment, monitoring, and prevention" of adverse effects with phar ...

Regulatory Affairs Regulatory affairs (RA), also called government affairs, is a profession within regulated industries, such as pharmaceuticals, medical devices, cosmetics, agrochemicals (plant protection products and fertilizers), energy, banking, telecom etc. Reg ...

Competitive Intelligence Competitive intelligence (CI) is the process and forward-looking practices used in producing knowledge about the competitive environment to improve organizational performance. It involves the systematic collection and analysis of information from ...

- also referred to as Pharma Intelligence within its industry, and

Pharmacoeconomics Pharmacoeconomics refers to the scientific discipline that compares the value of one pharmaceutical drug or drug therapy to another. It is a sub-discipline of health economics. A pharmacoeconomic study evaluates the cost (expressed in monetary te ...

as well as investors and publishers of medical content.

Collaborations

The capability for inter-group collaboration attracted attention from the

Bill & Melinda Gates Foundation The Bill & Melinda Gates Foundation (BMGF), a merging of the William H. Gates Foundation and the Gates Learning Foundation, is an American private foundation founded by Bill Gates and Melinda French Gates. Based in Seattle, Washington, it w ...

, who in 2008 awarded CDD with a two million dollar grant being used to support researchers combating

tuberculosis Tuberculosis (TB) is an infectious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in w ...

. In 2010,

GlaxoSmithKline GSK plc, formerly GlaxoSmithKline plc, is a British Multinational corporation, multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a Mergers and acquisitions, merger of Gl ...

released 13,471 molecules screened for activity against

malaria Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or deat ...

to the public. These molecules and their associated screening data are available via CDD Public, as well in as the National Library of Medicine's

PubChem PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information (NCBI), a component of the National Library of Medicine, which is part o ...

and the European Bioinformatics Institute's

ChEMBL ChEMBL or ChEMBLdb is a manually curated chemical database of bioactive molecules with drug-like properties. It is maintained by the European Bioinformatics Institute (EBI), of the European Molecular Biology Laboratory (EMBL), based at the Wel ...

database. This data has served as the basis for several

cheminformatics Cheminformatics (also known as chemoinformatics) refers to use of physical chemistry theory with computer and information science techniques—so called "''in silico''" techniques—in application to a range of descriptive and prescriptive proble ...

analyses. In February 2011 CDD began participating in the collaborative MM4TB project led by Stewart Cole and including participants from AstraZeneca and Sanofi Aventis.

References

{{Reflist

External links

CDD's official homepage for CDD Vault

PharmaKB's homepage

CDD's official homepage for BioHarmony
Software companies based in California Companies established in 2004 Chemical databases Software companies of the United States