Clopimozide (R-29,764) is a

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics m ...

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhal ...

of the

diphenylbutylpiperidine Diphenylbutylpiperidines are a class of typical antipsychotic drugs which were all synthesized, developed, and marketed by Janssen Pharmaceutica. They include: * Clopimozide (R-29,764) * Fluspirilene (Redeptin) * Penfluridol (Semap, Micefal, L ...

class. It is very

potent Potent may refer to: * for the heraldic fur *Warren Potent for the Australian Olympic medalist in shooting See also: *Potency (disambiguation) Potency may refer to: * Potency (pharmacology), a measure of the activity of a drug in a biologica ...

and has an extremely long duration of action, lasting at least one week with a single dose. It was developed by

Janssen Pharmaceutica Janssen Pharmaceuticals is a pharmaceutical company headquartered in Beerse, Belgium, and wholly-owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceuticals was purchased by New Jersey-based America ...

but was never marketed.

Synthesis

* 3786-28-0also used for:

Domperidone Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). It raises th ...

, Halopemide & Axamozide. *

312-04-7 31 may refer to: * 31 (number) Years * 31 BC * AD 31 * 1931 CE ('31) * 2031 CE ('31) Music * ''Thirty One'' (Jana Kramer album), 2015 * ''Thirty One'' (Jarryd James album), 2015 * "Thirty One", a song by Karma to Burn from the album '' Wil ...

is also used for:

Amperozide Amperozide is an atypical antipsychotic of the diphenylbutylpiperazine class which acts as an antagonist at the 5-HT2A receptor. It does not block dopamine receptors as with most antipsychotic drugs, but does inhibit dopamine release, and alt ...

Fluspirilene Fluspirilene (Redeptin, Imap, R6218) is a diphenylbutylpiperidine typical antipsychotic drug, used for the treatment of schizophrenia. It is administered intramuscularly. It was discovered at Janssen Pharmaceutica in 1963.C. Janssen, NV Res. La ...

Pimozide Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weight basis ...

Penfluridol Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generation diphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968. Related to other diphenylbutylpiperidine antipsychotics, pimozide and flu ...

Lidoflazine Lidoflazine is a piperazine calcium channel blocker. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at Janssen Pharmaceutica in 1964. Physical properties Solubility at room temperature Extracted from ...

R 1624

The alkylation between 5-Chloro-1-(4-Piperidyl)-2-Benzimidazolinone 3786-28-0(1) and 1,1'-(4-Chlorobutylidene)bis(4-fluorobenzene)

(2) gives clopimozide (3).

References

Benzimidazoles Chloroarenes 1-(4,4-Bis(4-fluorophenyl)butyl)piperidines Ureas Typical antipsychotics {{nervous-system-drug-stub