Clocinnamox
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Clocinnamox (CCAM or C-CAM; developmental code name NIH-10443) is a selective and irreversible
antagonist An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain.μ-opioid receptor The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins. They are also referred to as μ(''mu'')-opioid peptide (MOP) receptors. The prototypical ...
. Closely related compounds include
methocinnamox Methocinnamox (MCAM) is an opioid receptor antagonist. It is a pseudo-irreversible non-competitive antagonist of the μ-opioid receptor and a competitive antagonist of the κ- and δ-opioid receptors. The drug has a very long duration of acti ...
(MCAM) and methoclocinnamox (MCCAM). They were derived via
structural modification Molecular modification is chemical alteration of a known and previously characterized lead compound for the purpose of enhancing its usefulness as a drug. This could mean enhancing its specificity for a particular body target site, increasing its ...
of
buprenorphine Buprenorphine, sold under the brand name Subutex among others, is an opioid used to treat opioid use disorder, acute pain, and chronic pain. It can be used under the tongue (sublingual), in the cheek (buccal), by injection (intravenous a ...
. Clocinnamox was first described in the
scientific literature Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical ...
by 1992.


References

4-Chlorophenyl compounds 4,5-Epoxymorphinans Abandoned drugs Acrylamides Amides Cyclopropyl compounds Heterocyclic compounds with 5 rings Mu-opioid receptor antagonists Nitrogen heterocycles Oxygen heterocycles {{Analgesic-stub