''Cleistanthus collinus'' is a plant species first described by

Roxburgh Roxburgh () is a civil parish and formerly a royal burgh, in the historic county of Roxburghshire in the Scottish Borders, Scotland. It was an important trading burgh in High Medieval to early modern Scotland. In the Middle Ages it had at lea ...

, with its current name after Bentham and Hooker; it is included in the family

Phyllanthaceae Phyllanthaceae is a Family (biology), family of flowering plants in the eudicot Order (biology), order Malpighiales. It is most closely related to the family Picrodendraceae.Kenneth J. Wurdack and Charles C. Davis. 2009. "Malpighiales phylogeneti ...

. The

IUCN The International Union for Conservation of Nature (IUCN) is an international organization working in the field of nature conservation and sustainable use of natural resources. Founded in 1948, IUCN has become the global authority on the status ...

categorizes this species as vulnerable. No subspecies are listed in the

Catalogue of Life The Catalogue of Life (CoL) is an online database that provides an index of known species of animals, plants, fungi, and microorganisms. It was created in 2001 as a partnership between the global Species 2000 and the American Integrated Taxono ...

Properties

''Cleistanthus collinus'' (Karra) contains a plant poison also called ''oduvan'' (

Tamil Tamil may refer to: People, culture and language * Tamils, an ethno-linguistic group native to India, Sri Lanka, and some other parts of Asia **Sri Lankan Tamils, Tamil people native to Sri Lanka ** Myanmar or Burmese Tamils, Tamil people of Ind ...

), ''kadise'' (

Kannada Kannada () is a Dravidian language spoken predominantly in the state of Karnataka in southwestern India, and spoken by a minority of the population in all neighbouring states. It has 44 million native speakers, and is additionally a ...

), ''Vadisaku'' (

Telugu Telugu may refer to: * Telugu language, a major Dravidian language of South India ** Telugu literature, is the body of works written in the Telugu language. * Telugu people, an ethno-linguistic group of India * Telugu script, used to write the Tel ...

), ''Oduku'' (

Malayalam Malayalam (; , ) is a Dravidian languages, Dravidian language spoken in the Indian state of Kerala and the union territories of Lakshadweep and Puducherry (union territory), Puducherry (Mahé district) by the Malayali people. It is one of ...

) and Gaja Madara ( Sinhala) . Ingestion of its leaves or a decoction of its leaves causes

hypokalemia Hypokalemia is a low level of potassium (K+) in the blood serum. Mild low potassium does not typically cause symptoms. Symptoms may include feeling tired, leg cramps, weakness, and constipation. Low potassium also increases the risk of an a ...

(

kaliuresis Kaliuresis () or kaluresis () is the condition of excreting potassium in the urine. Thiazide diuretics are used to treat patients with heart failure. Their goal is to decrease the amount of salt (sodium chloride) in the body by decreasing the amou ...

and

cardiac arrhythmia Arrhythmias, also known as cardiac arrhythmias, are irregularities in the heartbeat, including when it is too fast or too slow. Essentially, this is anything but normal sinus rhythm. A resting heart rate that is too fast – above 100 beat ...

s),

metabolic acidosis Metabolic acidosis is a serious electrolyte disorder characterized by an imbalance in the body's acid-base balance. Metabolic acidosis has three main root causes: increased acid production, loss of bicarbonate, and a reduced ability of the kidn ...

hypotension Hypotension, also known as low blood pressure, is a cardiovascular condition characterized by abnormally reduced blood pressure. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood and is ...

and hypoxia probably due to distal renal tubular acidosis,

ARDS Ards (or ARDS, ARDs) may refer to: Medical * ARDS, Acute respiratory distress syndrome * ARDs, age-related diseases Places * Ards Peninsula, Northern Ireland ** Ards (territory), several historical territorial divisions on the Ards Peninsula ...

and toxin induced

vasodilatation Vasodilation, also known as vasorelaxation, is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. Blood vessel ...

respectively. Hypokalemia and acidosis probably also induces

rhabdomyolysis Rhabdomyolysis (shortened as rhabdo) is a condition in which damaged skeletal muscle breaks down rapidly. Symptoms may include muscle pains, weakness, vomiting, and confusion. There may be tea-colored urine or an irregular heartbeat. Some o ...

resulting in myoglobinuric

kidney failure Kidney failure, also known as renal failure or end-stage renal disease (ESRD), is a medical condition in which the kidneys can no longer adequately filter waste products from the blood, functioning at less than 15% of normal levels. Kidney fa ...

and

neuromuscular A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber. It allows the motor neuron to transmit a signal to the muscle fiber, causing muscle contraction. Muscles require innervation to ...

weakness. Its effects are probably mediated by injury to the distal renal tubules,

pulmonary The lungs are the primary organs of the respiratory system in many animals, including humans. In mammals and most other tetrapods, two lungs are located near the backbone on either side of the heart. Their function in the respiratory syste ...

epithelium Epithelium or epithelial tissue is a thin, continuous, protective layer of cells with little extracellular matrix. An example is the epidermis, the outermost layer of the skin. Epithelial ( mesothelial) tissues line the outer surfaces of man ...

and peripheral blood vessels due to

glutathione Glutathione (GSH, ) is an organic compound with the chemical formula . It is an antioxidant in plants, animals, fungi, and some bacteria and archaea. Glutathione is capable of preventing damage to important cellular components caused by sources ...

depletion (animal studies have shown benefit with ''N''-acetylcysteine).

Gallery

Medicinal Plant Cleistanthus collinus.jpg, Karra at fruiting Cleistanthus collinus (Garari) in Narsapur forest, AP W IMG 0166.jpg Cleistanthus collinus (Garari) in Narsapur forest, AP W IMG 0168.jpg Cleistanthus collinus (Garari) in Narsapur forest, AP W IMG 0169.jpg

References

Benth. ex Hook.f., 1887 ''In: Fl. Brit. India 5: 274'' * * {{Taxonbar, from=Q13110806 collinus