Class II PI 3-kinases are a subgroup of the enzyme family,
phosphoinositide 3-kinase
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which i ...
that share a common protein domain structure, substrate specificity and method of activation.
Class II PI 3-kinases were the most recently identified class of PI 3-kinases.
There are three class II PI 3-kinase isoforms expressed in mammalian cells;
*PI3K-C2α encoded by the
PIK3C2A gene
*PI3K-C2β encoded by the
PIK3C2B gene
*PI3K-C2γ encoded by the
PIK3C2G gene
See also
*
Phosphoinositide 3-kinase
Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which i ...
References
*Stein RC (2001) Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment ''Endocr Relat Cancer'' 8:237-24
*Foster FM, Traer CJ, Abraham SM, and Fry MJ (2003) The phosphoinositide (PI) 3-kinase family ''J Cell Sci'' 116:3037-304
*Vanhaesebroeck B, Waterfield MD.(1999) Signaling by distinct classes of phosphoinositide 3-kinases. ''Exp Cell Res.'' 253(1):239-5
EC 2.7.1
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