Cilansetron is an experimental drug that is a 5-HT₃ antagonist under

development Development or developing may refer to: Arts *Development (music), the process by which thematic material is reshaped * Photographic development *Filmmaking, development phase, including finance and budgeting * Development hell, when a proje ...

by Solvay Pharmaceuticals. 5-HT₃ receptors are responsible for causing many things from nausea to excess

bowel movements The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The tract is the largest of the body's systems, after the cardiovascular syste ...

. In conditions such as

irritable bowel syndrome Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by a group of symptoms that commonly include abdominal pain, abdominal bloating, and changes in the consistency of bowel movements. These symptoms may ...

(IBS), the receptors have become faulty or oversensitive. 5-HT₃ antagonists work by blocking the nervous and chemical signals from reaching these receptors. Studies have shown that the drug can improve quality of life in men and women with diarrhea-predominant IBS.General info on Cilansetron
/ref> Cilansetron is the first 5-HT antagonist specifically designed for IBS that is effective in men as well as women. In 2005, Solvay received response from the U.S. Food and Drug Administration that cilansertron is not approvable without additional clinical trials; further development has been discontinued.

References

{{Serotonergics 5-HT3 antagonists Imidazoles Ketones Drugs developed by AbbVie Abandoned drugs Heterocyclic compounds with 4 rings