Ciclafrine ( INN) is a

sympathomimetic Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system. Examples of sympathomimetic effects include increases in hea ...

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace amin ...

and

antihypertensive Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests tha ...

that was never marketed.

Synthesis

Ciclafrine can be prepared by the reaction of

norfenefrine Norfenefrine (INN; also known as ''meta''-octopamine, 3-octopamine, and 3,β-dihydroxyphenethylamine) is an adrenergic agent used as a sympathomimetic drug which is marketed in Europe, Japan, and Mexico. Along with its structural isomer ''p''-oc ...

with cycloheptanone. : Ciclafrine synthesis

References

Antihypertensive agents Phenylethanolamine ethers Oxazolidines Spiro compounds Abandoned drugs {{antihypertensive-stub