Ciclafrine (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...

) is a

sympathomimetic Sympathomimetic drugs (also known as adrenergic drugs and adrenergic amines) are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system. Examples of sympathomimetic effects include increases in heart ...

phenethylamine Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine, which acts as a central nervous system stimulant in humans. In the brain, phenethylamine regulates monoamine neurotransmission by binding to trace am ...

and

antihypertensive Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that ...

that was never marketed.

Synthesis

Ciclafrine can be prepared by the reaction of

norfenefrine Norfenefrine (International Nonproprietary Name, INN; also known as ''meta''-octopamine, 3-octopamine, and 3,β-dihydroxyphenethylamine) is an adrenergic drug, agent used as a sympathomimetic drug which is marketed in Europe, Japan, and Mexico. A ...

with

cycloheptanone Cycloheptanone, (CH2)6CO, is a cyclic ketone also referred to as suberone. It is a colourless volatile liquid. Cycloheptanone is used as a precursor for the synthesis of pharmaceuticals. Synthesis In 1836, French chemist Jean-Baptiste Boussinga ...

. :

References

Antihypertensive agents Phenylethanolamine ethers Oxazolidines Spiro compounds Abandoned drugs {{antihypertensive-stub