Chromosome 17 is one of the 23 pairs of

chromosome A chromosome is a package of DNA containing part or all of the genetic material of an organism. In most chromosomes, the very long thin DNA fibers are coated with nucleosome-forming packaging proteins; in eukaryotic cells, the most import ...

s in

human Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing ...

s. People normally have two copies of this chromosome. Chromosome 17 spans more than 84 million

base pair A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix and contribute to the folded structure of both DNA ...

s (the building material of

DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...

) and represents between 2.5 and 3% of the total DNA in cells. Chromosome 17 contains the

Homeobox A homeobox is a Nucleic acid sequence, DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. Mutations in a homeobox may change large-scale anatomical features of ...

gene cluster A gene cluster is a group of two or more genes found within an organism's DNA that encode similar peptide, polypeptides or proteins which collectively share a generalized function and are often located within a few thousand base pairs of each othe ...

Genes

Number of genes

The following are some of the gene count estimates of human chromosome 17. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). The most conservative estimate, from CCDS, represents a lower bound on the total number of human protein-coding genes.

Gene list

The following is a partial list of genes on human chromosome 17. For complete list, see the link in the infobox on the right. The following are some of the genes and their corresponding Cytogenetic location on chromosome 17:

p-arm

q-arm

Diseases and disorders

The following diseases are related to genes on chromosome 17: * 17q12 microdeletion syndrome * Koolen–de Vries syndrome * Alexander disease *

Andersen–Tawil syndrome Andersen–Tawil syndrome, also called Andersen syndrome and long QT syndrome 7, is a rare genetic disorder affecting several parts of the body. The three predominant features of Andersen–Tawil syndrome include disturbances of the electrical f ...

Aneurysmal bone cyst Aneurysmal bone cyst (ABC) is a non-cancerous bone tumor composed of multiple varying sizes of spaces in a bone which are filled with blood. The term is a misnomer, as the lesion is neither an aneurysm nor a cyst. It generally presents with ...

Bipolar disorder Bipolar disorder (BD), previously known as manic depression, is a mental disorder characterized by periods of Depression (mood), depression and periods of abnormally elevated Mood (psychology), mood that each last from days to weeks, and in ...

* Birt–Hogg–Dubé syndrome *

Bladder cancer Bladder cancer is the abnormal growth of cells in the bladder. These cells can grow to form a tumor, which eventually spreads, damaging the bladder and other organs. Most people with bladder cancer are diagnosed after noticing blood in thei ...

Breast cancer Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a Breast lump, lump in the breast, a change in breast shape, dimpling of the skin, Milk-rejection sign, milk rejection, fluid coming from the nipp ...

* Bruck syndrome * Campomelic dysplasia * Canavan disease * Cerebroretinal microangiopathy with calcifications and cysts * Charcot–Marie–Tooth disease * Chronic lymphocytic leukaemia, tp53 * Corticobasal degeneration * Cystinosis * Depression * Ehlers–Danlos syndrome * Epidermodysplasia verruciformis * Frontotemporal dementia and parkinsonism linked to chromosome 17 *

Galactosemia Galactosemia (British galactosaemia, from Greek γαλακτόζη + αίμα, meaning galactose + blood, accumulation of galactose in blood) is a rare genetics, genetic Metabolism, metabolic Disease, disorder that affects an individual's ability t ...

* Glycogen storage disease type II ( Pompe disease) * Hereditary neuropathy with liability to pressure palsies * Howel–Evans syndrome * Li–Fraumeni syndrome * Maturity onset diabetes of the young type 5 * Miller–Dieker syndrome * Multiple synostoses syndrome * Neurofibromatosis type I * Nonsyndromic deafness *

Obsessive–compulsive disorder Obsessive–compulsive disorder (OCD) is a mental disorder in which an individual has intrusive thoughts (an ''obsession'') and feels the need to perform certain routines (''Compulsive behavior, compulsions'') repeatedly to relieve the dis ...

* Osteogenesis imperfecta * Potocki–Lupski syndrome * Proximal symphalangism * Sanfilippo syndrome * Smith–Magenis syndrome * Usher syndrome * Very long-chain acyl-coenzyme A dehydrogenase deficiency * Von Gierke's syndrome

Genes

Number of genes

Gene list

p-arm

q-arm

Diseases and disorders

Cytogenetic band

References

External links