The chondrocranium (or ''cartilaginous

neurocranium In human anatomy, the neurocranium, also known as the braincase, brainpan, or brain-pan is the upper and back part of the skull, which forms a protective case around the brain. In the human skull, the neurocranium includes the calvaria or sk ...

'') is the primitive

cartilaginous Cartilage is a resilient and smooth type of connective tissue. In tetrapods, it covers and protects the ends of long bones at the joints as articular cartilage, and is a structural component of many body parts including the rib cage, the neck a ...

skeletal A skeleton is the structural frame that supports the body of an animal. There are several types of skeletons, including the exoskeleton, which is the stable outer shell of an organism, the endoskeleton, which forms the support structure inside ...

structure of the fetal

skull The skull is a bone protective cavity for the brain. The skull is composed of four types of bone i.e., cranial bones, facial bones, ear ossicles and hyoid bone. However two parts are more prominent: the cranium and the mandible. In humans, t ...

that grows to envelop the rapidly growing

embryo An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm ...

nic

brain The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It consists of nervous tissue and is typically located in the head ( cephalization), usually near organs for special ...

.Salentijn, L. ''Biology of Mineralized Tissues: Prenatal Skull Development'',

Columbia University College of Dental Medicine The Columbia University College of Dental Medicine, often abbreviated CDM, is one of the twenty graduate and professional schools of Columbia University. It is located at 630 West 168th Street in Manhattan, New York City. According to American D ...

post-graduate dental lecture series, 2007 The chondrocranium in different species can vary greatly, but in general it is made up of five components, the sphenoids, the mesethmoid, the occipitals, the optic capsules and the nasal capsules. In

human Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, ...

s, the chondrocranium begins forming at 28 days from

mesenchymal Mesenchyme () is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood or bone. The interactions between mesenchyme and epithelium help to form nearly every ...

condensations and is fully formed between week 7 and 9 of fetal development. While the majority of the chondrocranium is succeeded by the bony skull, some components do persist into adulthood. In

cartilaginous fishes Chondrichthyes (; ) is a class that contains the cartilaginous fishes that have skeletons primarily composed of cartilage. They can be contrasted with the Osteichthyes or ''bony fishes'', which have skeletons primarily composed of bone tissue. ...

(e.g.

shark Sharks are a group of elasmobranch fish characterized by a cartilaginous skeleton, five to seven gill slits on the sides of the head, and pectoral fins that are not fused to the head. Modern sharks are classified within the clade Selachi ...

s and rays) and

agnatha Agnatha (, Ancient Greek 'without jaws') is an infraphylum of jawless fish in the phylum Chordata, subphylum Vertebrata, consisting of both present ( cyclostomes) and extinct (conodonts and ostracoderms) species. Among recent animals, cyclos ...

ns (e.g.

lamprey Lampreys (sometimes inaccurately called lamprey eels) are an ancient extant lineage of jawless fish of the order Petromyzontiformes , placed in the superclass Cyclostomata. The adult lamprey may be characterized by a toothed, funnel-like s ...

s and

hagfish Hagfish, of the class Myxini (also known as Hyperotreti) and order Myxiniformes , are eel-shaped, slime-producing marine fish (occasionally called slime eels). They are the only known living animals that have a skull but no vertebral column, ...

), the chondrocranium persists throughout life.Kent, G.C & Miller, L. (1997): Comparative Anatomy of the Vertebrates. Wm. C. Brown Publishers. . Embryologically, the chondrocranium represents the basal cranial structure, and lays the base for the formation of the

endocranium The endocranium in comparative anatomy is a part of the skull base in vertebrates and it represents the basal, inner part of the cranium. The term is also applied to the outer layer of the dura mater in human anatomy. Structure Structurally, t ...

Divisions

The portion of the chondrocranium that is associated with the

notochord In anatomy, the notochord is a flexible rod which is similar in structure to the stiffer cartilage. If a species has a notochord at any stage of its life cycle (along with 4 other features), it is, by definition, a chordate. The notochord cons ...

is termed the chordal chondrocranium and is formed from

mesoderm The mesoderm is the middle layer of the three germ layers that develops during gastrulation in the very early development of the embryo of most animals. The outer layer is the ectoderm, and the inner layer is the endoderm.Langman's Medical Emb ...

ally-derived

mesenchyme Mesenchyme () is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood or bone. The interactions between mesenchyme and epithelium help to form nearly every ...

. The more

rostral Rostral may refer to: Anatomy * Rostral (anatomical term), situated toward the oral or nasal region * Rostral bone, in ceratopsian dinosaurs * Rostral organ, of certain fish * Rostral scale, in snakes and scaled reptiles Other uses * Rostral col ...

portion of the chondrocranium that lie anterior to the notochord constitutes the prechordal chondrocranium, and is derived primarily from

neural crest Neural crest cells are a temporary group of cells unique to vertebrates that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, ...

-derived mesenchyme.

References

Vertebrate developmental biology Skull {{musculoskeletal-stub

Divisions

See also

References