Chlorodyne Bottles And Lozenge Tins
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Chlorodyne was one of the best known
patent medicine A patent medicine (sometimes called a proprietary medicine) is a non-prescription medicine or medicinal preparation that is typically protected and advertised by a trademark and trade name, and claimed to be effective against minor disorders a ...
s sold in the British Isles. It was invented in the 19th century by a Dr.
John Collis Browne Dr. John Collis Browne MRCS (1819–1884) was a British Army officer, inventor of items for yachts and the originator of the medicine Chlorodyne. Serving as surgeon with the 98th Regiment of Foot in India in 1848, Browne developed Chlorodyne ...
, a doctor in the
British Indian Army The Indian Army was the force of British Raj, British India, until Indian Independence Act 1947, national independence in 1947. Formed in 1895 by uniting the three Presidency armies, it was responsible for the defence of both British India and ...
; its original purpose was in the treatment of
cholera Cholera () is an infection of the small intestine by some Strain (biology), strains of the Bacteria, bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea last ...
. Browne sold his formula to the pharmacist
John Thistlewood Davenport John Thistlewood Davenport (1817–1901) was an English pharmacist and businessman.Deaths
''The Chemist ...
, who advertised it widely, as a treatment for
cholera Cholera () is an infection of the small intestine by some Strain (biology), strains of the Bacteria, bacterium ''Vibrio cholerae''. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea last ...
,
diarrhea Diarrhea (American English), also spelled diarrhoea or diarrhœa (British English), is the condition of having at least three loose, liquid, or watery bowel movements in a day. It often lasts for a few days and can result in dehydration d ...
,
insomnia Insomnia, also known as sleeplessness, is a sleep disorder where people have difficulty sleeping. They may have difficulty falling asleep, or staying asleep for as long as desired. Insomnia is typically followed by daytime sleepiness, low ene ...
,
neuralgia Neuralgia (Greek ''neuron'', "nerve" + ''algos'', "pain") is pain in the distribution of a nerve or nerves, as in intercostal nerve, intercostal neuralgia, trigeminal neuralgia, and glossopharyngeal nerve, glossopharyngeal neuralgia. Classifica ...
,
migraine Migraine (, ) is a complex neurological disorder characterized by episodes of moderate-to-severe headache, most often unilateral and generally associated with nausea, and light and sound sensitivity. Other characterizing symptoms may includ ...
s, etc. As its principal ingredients were a mixture of
laudanum Laudanum is a tincture of opium containing approximately 10% powdered opium by weight (the equivalent of 1% morphine). Laudanum is prepared by dissolving extracts from the opium poppy (''Papaver somniferum'') in alcohol (ethanol). Reddish-br ...
(an alcoholic solution of
opium Opium (also known as poppy tears, or Lachryma papaveris) is the dried latex obtained from the seed Capsule (fruit), capsules of the opium poppy ''Papaver somniferum''. Approximately 12 percent of opium is made up of the analgesic alkaloid mor ...
), tincture of
cannabis ''Cannabis'' () is a genus of flowering plants in the family Cannabaceae that is widely accepted as being indigenous to and originating from the continent of Asia. However, the number of species is disputed, with as many as three species be ...
, and
chloroform Chloroform, or trichloromethane (often abbreviated as TCM), is an organochloride with the formula and a common solvent. It is a volatile, colorless, sweet-smelling, dense liquid produced on a large scale as a precursor to refrigerants and po ...
, it readily lived up to its claims of relieving pain, as a sedative, and for the treatment of diarrhea.


Imitations

Chlorodyne sold extremely well for many years; as its active ingredients were well known, local chemists' shops would also make up cheaper generic versions for sale to their customers. Here is an example of such a generic formulation, from ''Materia Medica'' by William Hale-White & A.H. Douthwaite, 21st edition (1932):
"Tinctura Chloroformi et Morphinæ Composita intended to be an imitation of the proprietary medicine called chlorodyne. Mix
chloroform Chloroform, or trichloromethane (often abbreviated as TCM), is an organochloride with the formula and a common solvent. It is a volatile, colorless, sweet-smelling, dense liquid produced on a large scale as a precursor to refrigerants and po ...
75, tincture of
capsicum ''Capsicum'' () is a genus of flowering plants in the Solanum, nightshade family Solanaceae, native to the Americas, cultivated worldwide for their edible fruit, which are generally known as "peppers" or "capsicum". Chili peppers grow on five s ...
25, tincture of Indian hemp 100,
oil of peppermint Peppermint (''Mentha'' × ''piperita'') is a hybrid species of mint, a cross between watermint and spearmint. Indigenous to Europe and the Middle East, the plant is now widely spread and cultivated in many regions of the world.Euro+Med Plantbas ...
2 and glycerin 250 with alcohol (20 per cent) 450. Dissolve
morphine Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (''Papaver somniferum''). It is mainly used as an analgesic (pain medication). There are ...
hydrochloride 10 in the mixture. Add to it diluted
hydrocyanic acid Hydrogen cyanide (formerly known as prussic acid) is a chemical compound with the formula HCN and structural formula . It is a highly toxic and flammable liquid that boils slightly above room temperature, at . HCN is produced on an industrial s ...
50 and enough alcohol (90 per cent) to make 1000. Strength. 1 millilitre contains chloroform 7.5 centimils; morphine hydrochloride 1 centigram; acidum hydrocyanicum dilutum 5 centimils. Dose 5 to 15 minims - 0.2 to 1ml
Besides the generics, a number of rival sellers marketed their own branded versions of the formula, brands such as "Freeman's", "Teasdale's", and "Towle's". It can be seen from the illustrations that the authenticity of these rival brands was hotly contested. Another version, Shinyaku (lit. "divine-medicine"), was developed in Japan and sold domestically for many years, although its most toxic ingredients were replaced over time for reasons of safety and legality.


Criticism from the medical community

Between 1861 and 1862 The British Medical Journal featured several pieces of criticism of chlorodyne including one lead article that featured it as an example of "Professional Testimonial-Mongers." Alongside this are two letters from practising doctors. Both include significant distaste at the repeated inclusion of advertisement for Chlorodyne from Dr. Browne in a previous issue. Furthermore scepticism of its usefulness over other opioids and a general distaste for its Homeopathic advertisement is a consistent theme.


Decline

Though the drug was effective in many ways, its high
opiate An opiate is an alkaloid substance derived from opium (or poppy straw). It differs from the similar term ''opioid'' in that the latter is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain ( ...
content also made it very addictive, and deaths from overdoses, either accidental or deliberate, became a frequent occurrence. A common feature of the coroner's report in such cases would be the description of the deceased's body being found in a flat or
bedsit A bedsit, bedsitter, or bed-sitting room is a form of accommodation common in some parts of the United Kingdom which consists of a single room per occupant with all occupants typically sharing a bathroom. Bedsits are included in a legal categor ...
littered with empty Chlorodyne bottles. Over the decades of the twentieth century, the cannabis was removed from the formulation, and the amount of opiates in the medicine were progressively reduced. The name of Collis Browne lives on in Britain in a mixture sold under the trade name "J Collis Browne's Mixture" for the relief of coughs and diarrhea. This modern formulation contains morphine and peppermint oil. The active ingredients per 5ml are: morphine hydrochloride equivalent to 1.0mg anhydrous morphine, peppermint oil 1.5 microlitres. The other ingredients are:
ethanol Ethanol (also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound with the chemical formula . It is an Alcohol (chemistry), alcohol, with its formula also written as , or EtOH, where Et is the ps ...
(alcohol),
benzoic acid Benzoic acid () is a white (or colorless) solid organic compound with the formula , whose structure consists of a benzene ring () with a carboxyl () substituent. The benzoyl group is often abbreviated "Bz" (not to be confused with "Bn," which ...
(E210),
capsicum ''Capsicum'' () is a genus of flowering plants in the Solanum, nightshade family Solanaceae, native to the Americas, cultivated worldwide for their edible fruit, which are generally known as "peppers" or "capsicum". Chili peppers grow on five s ...
tincture, caramel (E150),
menthol Menthol is an organic compound, specifically a Monoterpene, monoterpenoid, that occurs naturally in the oils of several plants in the Mentha, mint family, such as Mentha arvensis, corn mint and peppermint. It is a white or clear waxy crystallin ...
,
citric acid Citric acid is an organic compound with the formula . It is a Transparency and translucency, colorless Weak acid, weak organic acid. It occurs naturally in Citrus, citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, ...
(E330),
hypromellose Hypromellose ( INN), short for hydroxypropyl methylcellulose (HPMC), is a semisynthetic, inert, viscoelastic polymer used in eye drops, as well as an excipient and controlled-delivery component in oral medicaments, found in a variety of commerc ...
,
sorbitol Sorbitol (), less commonly known as glucitol (), is a sugar alcohol with a sweet taste which the human body metabolizes slowly. It can be obtained by reduction of glucose, which changes the converted aldehyde group (−CHO) to a primary alco ...
solution (E420), treacle (containing sucrose and fructose), purified water.


References

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See also

*
Leonard Smithers Leonard Charles Smithers (19 December 1861 – 19 December 1907) was a London bookseller and publisher associated with the Decadent movement of the late 19th century. Biography Born in Sheffield, England, Smithers worked as a solicitor after ...
Analgesics Patent medicines