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Chloe Meave Orkin is a British physician and Professor of
HIV/AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ...
medicine at
Queen Mary University of London Queen Mary University of London (QMUL, or informally QM, and previously Queen Mary and Westfield College) is a public university, public research university in Mile End, East London, England. It is a member institution of the federal University of ...
. She works as a consultant at the
Royal London Hospital The Royal London Hospital is a large teaching hospital in Whitechapel in the London Borough of Tower Hamlets. It is part of Barts Health NHS Trust. It provides district general hospital services for the City of London and Tower Hamlets and ...
,
Barts Health NHS Trust Barts Health NHS Trust is an NHS trust based in London, England. Established in 2012, it runs five hospitals throughout the City of London and East London, and is one of the largest NHS trusts in England. History The trust was established on ...
. She is an internationally renowned expert in HIV therapeutics and led the first phase III clinical trial of injectable anti-retrovirals. She is immediate past Chair of the British HIV Association, where she championed the ''Undetectable=Untransmittable'' (U=U) campaign within the United Kingdom. She is president elect of the Medical Women's Federation. Orkin is gay and was on the Top 100 Lesbian influencer lists in both the UK and in the US in 2020. She considers herself a medical activist and much of her work focuses on inequalities in healthcare and in Medicine.


Early life and education

Orkin was born in
Johannesburg, South Africa Johannesburg ( , , ; Zulu and xh, eGoli ), colloquially known as Jozi, Joburg, or "The City of Gold", is the largest city in South Africa, classified as a megacity, and is one of the 100 largest urban areas in the world. According to D ...
. She obtained her medical degree in 1995 from the
University of the Witwatersrand The University of the Witwatersrand, Johannesburg (), is a multi-campus South African public research university situated in the northern areas of central Johannesburg. It is more commonly known as Wits University or Wits ( or ). The university ...
and was the prize student in virology and microbiology. She began her clinical training at Chris Hani Baragwanath Hospital,
Soweto Soweto () is a township of the City of Johannesburg Metropolitan Municipality in Gauteng, South Africa, bordering the city's mining belt in the south. Its name is an English syllabic abbreviation for ''South Western Townships''. Formerly a se ...
in the 1990s. At the time, between 30 and 40% of medical inpatients were infected with
HIV The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immu ...
and Orkin herself, lost close friends to AIDS. She moved to the United Kingdom. In 1998, she completed her specialist training in
HIV The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immu ...
and Genitourinary Medicine at Chelsea and Westminster Hospital. Towards the end of her specialist training, Orkin moved to
Botswana Botswana (, ), officially the Republic of Botswana ( tn, Lefatshe la Botswana, label= Setswana, ), is a landlocked country in Southern Africa. Botswana is topographically flat, with approximately 70 percent of its territory being the Kal ...
together with nurse colleague and partner Flick Thorley to establish an
HIV/AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual ...
treatment programme in
Francistown Francistown is the second largest city in Botswana, with a population of about 103,417 and 147,122 inhabitants for its agglomeration at the 2022 census. and often described as the "''Capital of the North''" or as the natives would have it “''T ...
as part of the government anti-retroviral roll-out. In 2006, Orkin completed a MSc in Infectious Diseases from The
London School of Hygiene & Tropical Medicine The London School of Hygiene and Tropical Medicine (LSHTM) is a public university, public research university in Bloomsbury, central London, and a constituent college, member institution of the University of London that specialises in public h ...
.


Research and career

At the age of 29, Orkin was appointed as Consultant physician at
Barts Health NHS Trust Barts Health NHS Trust is an NHS trust based in London, England. Established in 2012, it runs five hospitals throughout the City of London and East London, and is one of the largest NHS trusts in England. History The trust was established on ...
. Her specialist interests are the development of novel antiretroviral therapies, blood-borne virus testing and health inequalities. In 2013, she led the Test Me East HIV testing campaign which was supported by David Furnish, Sir
Elton John Sir Elton Hercules John (born Reginald Kenneth Dwight; 25 March 1947) is a British singer, pianist and composer. Commonly nicknamed the "Rocket Man" after his 1972 hit single of the same name, John has led a commercially successful career a ...
and
Sadie Frost Sadie Liza Frost (née Vaughan; born 19 June 1965) is an English actress, producer and fashion designer, who ran fashion label Frost French (until its closure in 2011) and a film production company (Blonde to Black Pictures). Early life Frost ...
and covered by CNN, Channel 4 and ITV news. In 2015, she spearheaded ‘''Going Viral’'', a week-long campaign to raise awareness of blood-borne viruses. The week-long novel campaign offered
HIV The human immunodeficiency viruses (HIV) are two species of '' Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immu ...
,
Hepatitis B Hepatitis B is an infectious disease caused by the '' Hepatitis B virus'' (HBV) that affects the liver; it is a type of viral hepatitis. It can cause both acute and chronic infection. Many people have no symptoms during an initial infection. F ...
and
Hepatitis C Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, ...
testing in emergency departments around the United Kingdom utilising an opt-out testing strategy. The campaign was widely covered in the media and supported by several high profile celebrities, including actor Richard Wilson and DJ
Tim Westwood Timothy Westwood (born 3 October 1957) is a British DJ and presenter. He is often referred to by other DJs and artists appearing on his shows simply as Westwood. He was described by ''The Guardian'' in 2022 as "a veteran of the hip-hop scene ...
. She led the first ever phase III clinical trial into the use of injectable anti-retrovirals. After appearing on
ITV News ITV News is the branding of news programmes on the British television network ITV. ITV has a long tradition of television news. Independent Television News (ITN) was founded to provide news bulletins for the network in 1955, and has since con ...
to discuss the treatment, she was trolled on social media where many misogynistic and homophobic comments were made about her appearance and sexual identity. This experience led her to take action on gender and sexuality-based discrimination. Shortly after she stood for election and was elected Vice President of the Medical Women's Federation in 2019. Orkin has also served as Chair of the British HIV Association from 2017-2019 and is on the Governing Council for the
International AIDS Society The International AIDS Society (IAS) is the world's largest association of HIV/AIDS professionals, with 11,600 members from over 170 countries , including clinicians, people living with HIV, service providers, policy makers and others. It aims to r ...
. In 2018, Orkin and the British HIV Association announced their commitment to the ''Undetectable=Untransmittable'' (U=U) campaign. During the first wave of COVID-19 pandemic in the United Kingdom, she led on safe delivery of COVID-19 treatment trials at the 5 Barts Health NHS Trust hospitals including
NHS Nightingale London The NHS Nightingale Hospital London was the first of the NHS Nightingale Hospitals, temporary hospitals set up by National Health Service (England), NHS England for the COVID-19 pandemic in England, COVID-19 pandemic. It was housed in the ExCe ...
(the first non-hospital, non-military research delivery). Since then she has led the team that created a new clinical trial centre in a community library to deliver a large SARS CoV2 vaccine trials and was appointed as its clinical director. She has also led research into poor health outcomes in ethnically diverse people and on gender disparities in women's academic careers. She is lead investigator for the first COVID-19 vaccine trial in pregnant women.


Selected publications

HIV Anti-retroviral Therapy: * * * * * * COVID-19 Equality Research: * * Blood-borne Virus Testing in UK Emergency Department: *


Awards and honours

Orkin is a Fellow of the
Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...

FRCP
.


Personal life

Orkin is lesbian. She lives in London with her wife Flick Thorley, who was a highly regarded HIV specialist nurse at Chelsea and Westminster hospital and Charge Nurse at the London Lighthouse. They share a home with their three dogs and two cats.


References

{{DEFAULTSORT:Orkin, Chloe Living people Year of birth missing (living people) British women medical doctors British LGBT scientists LGBT physicians People from Johannesburg University of the Witwatersrand alumni Academics of Queen Mary University of London 21st-century LGBT people