Cheryl H. Arrowsmith is a Canadian structural biologist and is the Chief Scientist at the Toronto laboratory of the

Structural Genomics Consortium The Structural Genomics Consortium (SGC) is a public-private-partnership focusing on elucidating the functions and disease relevance of all proteins encoded by the human genome, with an emphasis on those that are relatively understudied. The SGC pl ...

. Her contributions to protein structural biology includes the use of NMR and

X-ray crystallography X-ray crystallography is the experimental science determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to diffract into many specific directions. By measuring the angle ...

to pursue structures of proteins on a proteome wide scale. She received her

Ph.D. A Doctor of Philosophy (PhD, Ph.D., or DPhil; Latin: or ') is the most common degree at the highest academic level awarded following a course of study. PhDs are awarded for programs across the whole breadth of academic fields. Because it is a ...

in chemistry at the

University of Toronto The University of Toronto (UToronto or U of T) is a public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institu ...

in 1987 and post-doctoral training at Stanford University working with Oleg Jardetzky. One of her areas of interest is the tumour suppressor

p53 p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often s ...

and related proteins. Her current research is to determine the 3-dimensional structures of human proteins of therapeutic relevance by structural proteomics. She has made significant contributions to

epigenetic In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are " ...

signaling in the context of drug discovery. Arrowsmith was named a Fellow of the

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsi ...

(AAAS) in 2015.

References

Living people University of Toronto alumni Canadian company founders Technology company founders Canadian women company founders Structural biologists Canadian geneticists Canadian biochemists Women biochemists Canadian women geneticists Canadian women biologists Canadian women chemists 21st-century Canadian women scientists 21st-century Canadian biologists 21st-century chemists Year of birth missing (living people) Place of birth missing (living people) Fellows of the American Association for the Advancement of Science {{Canada-scientist-stub