Charles Granville Rob (4 May 1913 – 26 July 2001) was a British surgeon who pioneered techniques in the repair of damaged
blood vessels
Blood vessels are the structures of the circulatory system that transport blood throughout the human body. These vessels transport blood cells, nutrients, and oxygen to the tissues of the body. They also take waste and carbon dioxide away fro ...
, particularly the operation to unblock arteries of the neck, known as
carotid endarterectomy
Carotid endarterectomy is a surgical procedure used to reduce the risk of stroke from carotid artery stenosis (narrowing the internal carotid artery). In endarterectomy, the surgeon opens the artery and removes the plaque. The plaque forms and ...
and of the
aorta
The aorta ( ) is the main and largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes ...
when treating
aortic aneurysms
An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size. They usually cause no symptoms except when ruptured. Occasionally, there may be abdominal, back, or leg pain. The prevalence of abdominal aortic ...
.
After graduating from
Cambridge University
, mottoeng = Literal: From here, light and sacred draughts.
Non literal: From this place, we gain enlightenment and precious knowledge.
, established =
, other_name = The Chancellor, Masters and Schola ...
Tunisian Campaign
The Tunisian campaign (also known as the Battle of Tunisia) was a series of battles that took place in Tunisia during the North African campaign of the Second World War, between Axis and Allied forces from 17 November 1942 to 13 May 1943. T ...
, where he received the
Military Cross
The Military Cross (MC) is the third-level (second-level pre-1993) military decoration awarded to officers and (since 1993) other ranks of the British Armed Forces, and formerly awarded to officers of other Commonwealth countries.
The MC i ...
.
After the
Second World War
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...
, he became the youngest chief of surgery at St. Mary's Hospital, London and he also lead the vascular surgery program at
St Mary's Hospital, London
St Mary's Hospital is an NHS hospital in Paddington, in the City of Westminster, London, founded in 1845. Since the UK's first academic health science centre was created in 2008, it has been operated by Imperial College Healthcare NHS Trust ...
where he carried out one of the world's first carotid endarterectomies and a year later performed the UK's first deceased donor human-to-human
kidney transplant
Kidney transplant or renal transplant is the organ transplant of a kidney into a patient with chronic kidney disease, end-stage kidney disease (ESRD). Kidney transplant is typically classified as deceased-donor (formerly known as cadaveric) or li ...
. His contributions paved the way for St Mary's in becoming a pioneering centre in
vascular surgery
Vascular surgery is a surgical subspecialty in which diseases of the vascular system, or arteries, veins and lymphatic circulation, are managed by medical therapy, minimally-invasive catheter procedures and surgical reconstruction. The specialt ...
Charles Rob was born on 4 May 1913 in Weybridge, England. His father was Joseph William Rob, a family physician, who came from the farming and landowning family in Catton near Thirsk, Yorkshire. The Robs traced their ancestry from Loch Lomond, Scotland where they owned a successful cattle droving business, which continued after they settled in Yorkshire in the 1680s. and his mother was a descendant of Edward "Grog" Vernon, the British Admiral who introduced diluted rum for Royal Navy sailors in the 18th century.
He was educated at Hordle House and
Oundle
Oundle () is a market town on the left bank of the River Nene in North Northamptonshire, England, which had a population of 5,735 at the time of the 2011 census. It is north of London and south-west of Peterborough. The town is home to Oundl ...
before going on to graduate from
St John's College, Cambridge
St John's College is a constituent college of the University of Cambridge founded by the Tudor matriarch Lady Margaret Beaufort. In constitutional terms, the college is a charitable corporation established by a charter dated 9 April 1511. Th ...
, in 1934. During his time there, he once climbed one of the spires of
King's College King's College or The King's College refers to two higher education institutions in the United Kingdom:
*King's College, Cambridge, a constituent of the University of Cambridge
*King's College London, a constituent of the University of London
It ca ...
to place an open umbrella on the top. He also joined the university air squadron to train to be a pilot. After receiving a reserve commission as a pilot in the
Royal Air Force
The Royal Air Force (RAF) is the United Kingdom's air and space force. It was formed towards the end of the First World War on 1 April 1918, becoming the first independent air force in the world, by regrouping the Royal Flying Corps (RFC) an ...
he transferred to
St Thomas's Hospital
St Thomas' Hospital is a large NHS teaching hospital in Central London, England. It is one of the institutions that compose the King's Health Partners, an academic health science centre. Administratively part of the Guy's and St Thomas' NHS F ...
for his clinical attachment. In 1937, he graduated with an MB from Cambridge University.
He became a member of the
Royal College of Surgeons
The Royal College of Surgeons is an ancient college (a form of corporation) established in England to regulate the activity of surgeons. Derivative organisations survive in many present and former members of the Commonwealth. These organisations ar ...
in 1937 and, after two years of surgical training at St Thomas's, he gained his FRCS.
Second World War
At the onset of the Second World War in 1939, Rob was at the
Royal Victoria Hospital, Montreal
The Royal Victoria Hospital (RVH) (french: Hôpital Royal Victoria), colloquially known as the "Royal Vic" or "The Vic", is a hospital in Montreal, Quebec, Canada. It forms the biggest base hospital of the McGill University Health Centre (MUHC) ...
, but shortly returned to St Thomas's hospital to work throughout
the Blitz
The Blitz was a German bombing campaign against the United Kingdom in 1940 and 1941, during the Second World War. The term was first used by the British press and originated from the term , the German word meaning 'lightning war'.
The Germa ...
(1940–1941). Here, he met Mary Dorothy Elaine Beazley, who had worked as secretary and secret courier to Royal Air Force officer William Wedgwood Benn, and had subsequently enrolled in the Florence Nightingale School. They married six weeks later and later had two sons and two daughters. Joseph William Rob, Peter James Rob, Caroline Rob Zaleski and Rebecca Rob Podore.
He was later made resident assistant surgeon at Hydestile Hospital, close to
Godalming
Godalming is a market town and civil parish in southwest Surrey, England, around southwest of central London. It is in the Borough of Waverley, at the confluence of the Rivers Wey and Ock. The civil parish covers and includes the settleme ...
and had also operated in
bunker
A bunker is a defensive military fortification designed to protect people and valued materials from falling bombs, artillery, or other attacks. Bunkers are almost always underground, in contrast to blockhouses which are mostly above ground. T ...
ed operating rooms at St. Mary's hospital.
He joined the
Royal Army Medical Corps
The Royal Army Medical Corps (RAMC) is a specialist corps in the British Army which provides medical services to all Army personnel and their families, in war and in peace. The RAMC, the Royal Army Veterinary Corps, the Royal Army Dental Corps ...
in November 1942 and was posted to the 1st Parachute Battalion as a surgical specialist. He took part in the mission to seize the
Souk-el-Arba Airfield
The Souk-el-Arba Airfields are a pair of World War II military airfields in Tunisia, located near what was at the time the village of Souk-el-Arba but since 1966 has been known as Jendouba. The location is approximately 130 km west-southwe ...
s and the road junction at
Béja
Béja ( ar, باجة ') is a city in Tunisia. It is the capital of the Béja Governorate. It is located from Tunis, between the Medjerdah River and the Mediterranean, against the foothills of the Khroumire, the town of Béja is situated on the ...
during the
Tunisian Campaign
The Tunisian campaign (also known as the Battle of Tunisia) was a series of battles that took place in Tunisia during the North African campaign of the Second World War, between Axis and Allied forces from 17 November 1942 to 13 May 1943. T ...
. Here, he performed more than 150 operations after converting the French garrison school into a hospital. He suffered a left tibia and kneecap fracture when a bomb fell, and was reported to have used his own blood to transfuse a wounded person. After 24 days, he had treated over 200 people.
He was awarded the
Military Cross
The Military Cross (MC) is the third-level (second-level pre-1993) military decoration awarded to officers and (since 1993) other ranks of the British Armed Forces, and formerly awarded to officers of other Commonwealth countries.
The MC i ...
for his efforts. After leaving Tunisia he took up command of a field surgical unit in Sicily and Italy and became lieutenant colonel.
Surgical career in England
Upon return to London after the Second World War, Rob resumed duties at St Thomas' Hospital and later became professor of surgery at the
University of London
The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degre ...
and St. Mary's Hospital in 1950. During his time as professor of surgery, he was involved in the vascular surgery programme and also became advisor to royalty and Winston Churchill.
Michael DeBakey
Michael Ellis DeBakey (September 7, 1908 – July 11, 2008) was a Lebanese-American general and cardiovascular surgeon, scientist and medical educator who became Chairman of the Department of Surgery, President, and Chancellor of Baylor College ...
performed the first
carotid endarterectomy
Carotid endarterectomy is a surgical procedure used to reduce the risk of stroke from carotid artery stenosis (narrowing the internal carotid artery). In endarterectomy, the surgeon opens the artery and removes the plaque. The plaque forms and ...
in 1953 and the procedure became better known after Rob and his colleagues performed one in 1954. The operation proved to reduce the risk of stroke in patients with significant blocked carotid arteries and he reported to have carried out more than 5000 of these operations in his lifetime. In addition, he introduced using frozen cadaver
arterial
An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pul ...
aortic aneurysms
An aortic aneurysm is an enlargement (dilatation) of the aorta to greater than 1.5 times normal size. They usually cause no symptoms except when ruptured. Occasionally, there may be abdominal, back, or leg pain. The prevalence of abdominal aortic ...
. In 1955, he presented his experiences of over 30 abdominal aortic aneurysms to the
Royal College of Surgeons
The Royal College of Surgeons is an ancient college (a form of corporation) established in England to regulate the activity of surgeons. Derivative organisations survive in many present and former members of the Commonwealth. These organisations ar ...
.
In 1955, Rob performed the UK's first recorded deceased donor renal transplant with Hammersmith hospital's surgeon
Jim Dempster
William James Dempster (15 March 1918 – 27 July 2008) was a Mozambican-born British surgeon and researcher in organ transplantation at St Mary’s Hospital, London. He published more than 100 scientific reviews and papers on kidney transplant ...
, at St Mary's Hospital. The recipient had developed acute renal failure following a septic abortion and was considered by Dempster as not ideal for transplant and an unnecessary fatal disaster. However, it instilled an interest in further transplantation developments at St Mary's, which became regarded as pioneers in this field.
Surgical career in the United States
In 1960 Rob accepted the position of chief of the Department of Surgery at the
University of Rochester
The University of Rochester (U of R, UR, or U of Rochester) is a private university, private research university in Rochester, New York. The university grants Undergraduate education, undergraduate and graduate degrees, including Doctorate, do ...
,
Strong Memorial Hospital
Strong Memorial Hospital (SMH) is an 886-bed medical facility, part of the University of Rochester Medical Center complex (abbreviated URMC), in Rochester, New York, United States. Opened in 1926, it is a major provider of both in-patient and o ...
and moved to the United States. Here, he continued to develop the technique of vein by-pass grafting.
In 1961, after recalling that cloth grafts had been used in the aortas of pigs, he used his
nylon
Nylon is a generic designation for a family of synthetic polymers composed of polyamides ( repeating units linked by amide links).The polyamides may be aliphatic or semi-aromatic.
Nylon is a silk-like thermoplastic, generally made from pet ...
shirt
A shirt is a cloth garment for the upper body (from the neck to the waist).
Originally an undergarment worn exclusively by men, it has become, in American English, a catch-all term for a broad variety of upper-body garments and undergarments. I ...
to successfully repair an aortic aneurysm in a human. After
debriding
Debridement is the medical removal of dead, damaged, or infected tissue to improve the healing potential of the remaining healthy tissue. Removal may be surgical, mechanical, chemical, autolytic (self-digestion), and by maggot therapy.
...
aneurysm
An aneurysm is an outward bulging, likened to a bubble or balloon, caused by a localized, abnormal, weak spot on a blood vessel wall. Aneurysms may be a result of a hereditary condition or an acquired disease. Aneurysms can also be a nidus ...
, the two open ends of the aorta needed to be rejoined with a graft, but the surgeons found that no graft was available to complete the procedure. To the surprise of his colleagues in theatre, Rob called for the shirt in his locker, cut out a rectangle and stitched it into a tube to be used as a graft, possibly the first use of a synthetic vascular graft in a human. The patient survived and the assistant recalled meeting the patient again eight years later.
After retiring in 1978, he moved to
East Carolina University
East Carolina University (ECU) is a public research university in Greenville, North Carolina. It is the fourth largest university in North Carolina.
Founded on March 8, 1907, as a teacher training school, East Carolina has grown from its origi ...
, taking an appointment as professor of surgery. Five years later he joined the
Uniformed Services University of the Health Sciences
Uniformed Services University of the Health Sciences (USU) is a health science university of the U.S. federal government. The primary mission of the school is to prepare graduates for service to the U.S. at home and abroad in the medical corps ...
at Bethesda, near Washington DC.
He was a past president of the International Society of Cardiovascular Surgery and the North American Chapter of the International Cardiovascular Society.
He was awarded the René Leriche prize of the
International Society of Surgery
The International Society of Surgery, or the Societe Internationale de Chirurgie, is an international society of surgeons founded in 1902. Apart from his medical innovations, he has been remembered for his saying on the treatment of a gangrenous limb: "The best treatment for the condition is rest. The best way to rest is sleep. The best way to get sleep is to relieve pain, and the best way to relieve pain is to give whiskey."
Selected publications
Rob published more than 200 papers. His book publications included:
* ''Operative Surgery''. 8 vols. Butterworths, London, 1956. (edited with Rodney Smith)