Charles A. Dinarello (born April 22, 1943) is a professor of medicine at the

University of Colorado at Denver The University of Colorado Denver (CU Denver) is a Public university, public research university located in downtown Denver, Colorado. It is part of the University of Colorado system. Established in 1912 as an extension of the University of C ...

. He is an expert on inflammatory

cytokines Cytokines () are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are produced by a broad range of cells, including immune cells like macrophages, B cell, B lymphocytes, T cell, T lymphocytes ...

, specifically

Interleukin 1 The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Discovery Discovery of these cytokines began with studies on t ...

Education and career

Dinarello received his

Doctor of Medicine A Doctor of Medicine (abbreviated MD, from the Latin language, Latin ) is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the ''MD'' denotes a professional degree of ph ...

in 1969 at

Yale University Yale University is a Private university, private Ivy League research university in New Haven, Connecticut, United States. Founded in 1701, Yale is the List of Colonial Colleges, third-oldest institution of higher education in the United Stat ...

and since 1996, he is professor of medicine at

University of Colorado School of Medicine The University of Colorado School of Medicine is the medical school of the University of Colorado system. It is located at the Anschutz Medical Campus in Aurora, Colorado, Aurora, Colorado, one of the four University of Colorado campuses, six mil ...

. He is also Professor of Experimental Medicine atqq3 the Radboud University Medical Center in Nijmegen, The Netherlands. Dinarello is considered one of the founding fathers of

having purified and cloned

interleukin-1 The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults. Discovery Discovery of these cytokines began with studies on t ...

. This important step established the validation of cytokines as mediators of disease, particularly of

inflammation Inflammation (from ) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin ''calor'', '' ...

. Current studies blocking IL-1 in humans supports Dinarello's and his co-workers pivotal contributions to cytokine biology and the pathogenesis of inflammatory diseases. He is fluent in English, Italian and German.

Awards

* 1993:

Ernst Jung Prize The Ernst Jung Prize is a prize awarded annually for excellence in biomedical sciences. The Ernst Jung Foundation, funded by Hamburg merchant Ernst Jung in 1967, has awarded the Ernst Jung Prize in Medicine, now €300,000, since 1976, and the lif ...

* 2006: Hamdan Award for Medical Research Excellence, awarded by Sheikh Hamdan bin Rashid Al Maktoum Award for Medical Sciences,

Dubai Dubai (Help:IPA/English, /duːˈbaɪ/ Help:Pronunciation respelling key, ''doo-BYE''; Modern Standard Arabic, Modern Standard Arabic: ; Emirati Arabic, Emirati Arabic: , Romanization of Arabic, romanized: Help:IPA/English, /diˈbej/) is the Lis ...

United Arab Emirates The United Arab Emirates (UAE), or simply the Emirates, is a country in West Asia, in the Middle East, at the eastern end of the Arabian Peninsula. It is a Federal monarchy, federal elective monarchy made up of Emirates of the United Arab E ...

* 2009:

Crafoord Prize The Crafoord Prize () is an annual science prize established in 1980 by Holger Crafoord, a Swedish industrialist, and his wife Anna-Greta Crafoord following a donation to the Royal Swedish Academy of Sciences. It is awarded jointly by the Acade ...

in Polyarthritis (together with

Tadamitsu Kishimoto is a Japanese immunologist known for research on IgM and cytokines, most famously, interleukin 6. He did postdoctoral work under Kimishige Ishizaka, the discoverer of IgE at Johns Hopkins University. He is listed by the Institute for Scientific ...

and

Toshio Hirano is a Japanese immunologist and academic, best known for his discovery of interleukin-6. Since August 2011, he has served as the 17th President of Osaka University. Chronology *1972—graduated from Graduate School of Medicine, Osaka Universit ...

) “for their pioneering work to isolate interleukins, determine their properties and explore their role in the onset of inflammatory diseases”. * 2009:

Albany Medical Center Prize The Albany Medical Center Prize in Medicine and Biomedical Research is the United States' second highest value prize in medicine and biomedical research, awarded by the Albany Medical Center. Among prizes for medicine worldwide, the Albany Medical ...

(shared with Ralph M. Steinman and Bruce A. Beutler) * 2010:

Paul Ehrlich and Ludwig Darmstaedter Prize The Paul Ehrlich and Ludwig Darmstaedter Prize is an annual award bestowed by the since 1952 for research in medicine. It carries a monetary prize of 120,000 Euro. The prize ceremony is traditionally held on the 14th of March, the birthday of Nob ...

* 2010: Novartis Prize in Clinical Immunology (together with Juerg Tschopp). * 2011: Foreign membership of the

Royal Netherlands Academy of Arts and Sciences The Royal Netherlands Academy of Arts and Sciences (, KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed in the Trippenhuis in Amsterdam. In addition to various advisory a ...

* 2020:

Tang Prize The Tang Prize ( zh, c=唐獎) is a set of Taiwanese biennial international awards bestowed in four fields: Sustainable Development, Biopharmaceutical Science, Sinology, and Rule of Law. Nomination and selection are conducted by an independent se ...

in Biopharmaceutical Science.Tang Prize 2020
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References

External links

Institutional WebsiteInformation about his research from the Royal Swedish Academy of Sciences

NAS
-> 1943 births Living people American immunologists Members of the Royal Netherlands Academy of Arts and Sciences Members of the United States National Academy of Sciences University of Colorado Denver faculty University of Denver faculty Yale University alumni {{US-physician-stub