A chancre ( )chancres
thefreedictionary is a painless

genital ulcer A genital ulcer is an open sore located on the genital area, which includes the vulva, penis, perianal region, or anus. Genital ulcers are most commonly caused by infectious agents (fungal infections, secondary bacterial infections, or sexually t ...

most commonly formed during the primary stage of

syphilis Syphilis () is a sexually transmitted infection caused by the bacterium ''Treponema pallidum'' subspecies ''pallidum''. The signs and symptoms depend on the stage it presents: primary, secondary, latent syphilis, latent or tertiary. The prim ...

. This infectious

lesion A lesion is any damage or abnormal change in the tissue of an organism, usually caused by injury or diseases. The term ''Lesion'' is derived from the Latin meaning "injury". Lesions may occur in both plants and animals. Types There is no de ...

forms around 21 days after the initial exposure to ''

Treponema pallidum ''Treponema pallidum'', formerly known as ''Spirochaeta pallida'', is a Microaerophile, microaerophilic, Gram-negative bacteria, gram-negative, spirochaete bacterium with subspecies that cause the diseases syphilis, bejel (also known as endemic ...

'', the

gram-negative Gram-negative bacteria are bacteria that, unlike gram-positive bacteria, do not retain the crystal violet stain used in the Gram staining method of bacterial differentiation. Their defining characteristic is that their cell envelope consists ...

spirochaete

bacterium Bacteria (; : bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the ...

causing syphilis, but can range from 10 to 90 days. Without treatment it may persist for two to six weeks before healing. Chancres transmit

through direct physical contact. These ulcers usually form on or around the

anus In mammals, invertebrates and most fish, the anus (: anuses or ani; from Latin, 'ring' or 'circle') is the external body orifice at the ''exit'' end of the digestive tract (bowel), i.e. the opposite end from the mouth. Its function is to facil ...

mouth A mouth also referred to as the oral is the body orifice through which many animals ingest food and animal communication#Auditory, vocalize. The body cavity immediately behind the mouth opening, known as the oral cavity (or in Latin), is also t ...

penis A penis (; : penises or penes) is a sex organ through which male and hermaphrodite animals expel semen during copulation (zoology), copulation, and through which male placental mammals and marsupials also Urination, urinate. The term ''pen ...

and

vulva In mammals, the vulva (: vulvas or vulvae) comprises mostly external, visible structures of the female sex organ, genitalia leading into the interior of the female reproductive tract. For humans, it includes the mons pubis, labia majora, lab ...

. Chancres are also associated with the

African trypanosomiasis African trypanosomiasis is an insect-borne parasitic infection of humans and other animals. Human African trypanosomiasis (HAT), also known as African sleeping sickness or simply sleeping sickness, is caused by the species ''Trypanosoma bru ...

(sleeping sickness), surrounding the area of the

tsetse fly Tsetse ( , or ) (sometimes spelled tzetze; also known as tik-tik flies) are large, biting flies that inhabit much of tropical Africa. Tsetse flies include all the species in the genus ''Glossina'', which are placed in their own family, Gloss ...

bite.

Similarities with chancroid

Chancres on the penile shaft due to a primary syphilitic infection caused by Treponema pallidum 6803 lores

Similarities between the conditions chancre and

chancroid Chancroid ( ) is a bacterial sexually transmitted infection characterized by painful sores on the genitalia. Chancroid is known to spread from one individual to another solely through sexual contact. However, there have been reports of accidenta ...

: * Both originate as pustules at the site of

inoculation Inoculation is the act of implanting a pathogen or other microbe or virus into a person or other organism. It is a method of artificially inducing immunity against various infectious diseases. The term "inoculation" is also used more generally ...

, and progress to ulcerated lesions * Both lesions are typically 1–2 cm in diameter * Both lesions are caused by sexually transmissible organisms * Both lesions typically appear on the genitals of infected individuals

Differences from chancroid

* Chancres can occur in the

pharynx The pharynx (: pharynges) is the part of the throat behind the human mouth, mouth and nasal cavity, and above the esophagus and trachea (the tubes going down to the stomach and the lungs respectively). It is found in vertebrates and invertebrates ...

as well as on the

genitals A sex organ, also known as a reproductive organ, is a part of an organism that is involved in sexual reproduction. Sex organs constitute the primary sex characteristics of an organism. Sex organs are responsible for producing and transporting ...

. Not to be confused with condylomata lata, which is seen in secondary syphilis.

Etymology

The word "chancre" () means "little ulcer" in

Old French Old French (, , ; ) was the language spoken in most of the northern half of France approximately between the late 8th -4; we might wonder whether there's a point at which it's appropriate to talk of the beginnings of French, that is, when it wa ...

. Related to the English "canker", they both come from the Latin ''cancer'', meaning "crab",medterms.com
which is a translation from the

Greek Greek may refer to: Anything of, from, or related to Greece, a country in Southern Europe: *Greeks, an ethnic group *Greek language, a branch of the Indo-European language family **Proto-Greek language, the assumed last common ancestor of all kno ...

word καρκίνος (''karkínos''), also meaning "crab".

References

{{Bacterial cutaneous infections Bacterium-related cutaneous conditions Medical signs Syphilis

Similarities with chancroid

Differences from chancroid

Etymology

See also

References