Cetiedil
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Cetiedil is a
vasodilator Vasodilation, also known as vasorelaxation, is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins, large arteries, and smaller arterioles. Blood vessel wal ...
and an anti-sickling agent.


Synthesis

The Clemmensen reduction of 3-thienylcyclohexyl-glycolic acid
CID:11064522
(1) gives cyclohexyl(thiophen-3-yl)acetic acid 6199-74-9(2). Esterification of the sodium salt of the resulting acid with 1-(2-chloroethyl)azepane 205-31-4(3) produces ''cetiedil'' (4).


References

Thiophenes Carboxylate esters Azepanes Cyclohexyl compounds {{cardiovascular-drug-stub