Central Institute for Experimental Animals (CIEA) (実験動物中央研究所) is a research center for experimental animals in

Japan Japan is an island country in East Asia. Located in the Pacific Ocean off the northeast coast of the Asia, Asian mainland, it is bordered on the west by the Sea of Japan and extends from the Sea of Okhotsk in the north to the East China Sea ...

. It was founded by

Tatsuji Nomura (May 15, 1922 – January 11, 2013) was a pioneer in the development of laboratory animals with the aim of assuring reproducibility of experimental results in medical research. He was Director of the Central Institute for Experimental Animals ( ...

in 1952 with the mission of improving the level of

biomedical research Medical research (or biomedical research), also known as health research, refers to the process of using scientific methods with the aim to produce knowledge about human diseases, the prevention and treatment of illness, and the promotion of ...

Main achievements and ongoing projects

*Establishment of the world first and only monitoring center for experimental animals in 1970. Appointed as an International Council for Laboratory Animal Science (ICLAS) Monitoring Center in 1979. *Development and establishment of Tg-PVR mouse, in which a human poliovirus receptor gene is introduced, used as a safety testing for oral polio vaccine. *Establishment of Tg-rasH2 mouse, in which a human prototype c-Ha-ras

oncogene An oncogene is a gene that has the potential to cause cancer. In tumor cells, these genes are often mutated, or expressed at high levels.

is introduced, and evaluation of their practical usefulness. Achieved a high level of accuracy in

carcinogen A carcinogen () is any agent that promotes the development of cancer. Carcinogens can include synthetic chemicals, naturally occurring substances, physical agents such as ionizing and non-ionizing radiation, and biologic agents such as viruse ...

icity testing for drugs and reduced the testing period to six months from the conventional two years' system. *Developing spinal cord injury model and

Parkinson's disease Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor system, motor and non-motor systems. Symptoms typically develop gradually and non-motor issues become ...

model using the

common marmoset The common marmoset (''Callithrix jacchus''), also called white-tufted marmoset or white-tufted-ear marmoset, is a New World monkey. It originally lived on the northeastern coast of Brazil, in the states of Piauí, Paraíba, Ceará, Rio Grande d ...

(

New World monkey New World monkeys are the five families of primates that are found in the tropical regions of Mexico, Central and South America: Callitrichidae, Cebidae, Aotidae, Pitheciidae, and Atelidae. The five families are ranked together as the Ceboi ...

). *Establishment of a severe immunodeficient mouse, NOD/Shi-scid, IL-2Rγnull mouse (NOD/SCID/IL-2Rγnull mouse,

NOG mouse A NOG (NOD/Shi-''scid''/IL-2Rγnull) mouse is a new generation of severely immunodeficient mouse, developed by Central Institute for Experimental Animals (CIEA) in 2000. The NOG mouse accepts heterologous cells much more easily compared with any ot ...

) and development of its applications to various animal experiments and testing systems.

ICLAS Monitoring Center

ICLAS Monitoring Center was established in the CIEA in 1979 and is the only center in the world for testing and verifying the quality of laboratory animals, under the direction of Dr.

with a conduct of International Council for Laboratory Animal Science (ICLAS).

History of the Monitoring Center

The Monitoring Center program came on the agenda in ICLAS early in the 1970s and the goal was set to assist the scientific bodies in finding animals of the highest quality. In 1979, a workshop was organized in Japan under the auspices of ICLAS and the International Cancer Research Workshop (ICREW) with representatives from the governing board of ICLAS, members of the ICLAS working party, and a number of experts from throughout the world. At that time, the planning of an ICLAS Monitoring Center System and the preparation of an International Manual on Genetic Monitoring, which had been in development for some time, was progressing well. The final proposal was later approved by the Board as a realistic and well-founded scheme that would give the users of laboratory animals a far better program and would help re-establish confidence in the system. The first ICLAS Genetic Monitoring Center in the world was then established in 1980 at CIEA in Japan, by Dr.

, Director of CIEA. This center had already served as an Asian Regional Coordinating Center in the ICLAS Reference Center project since 1979.

History

*1952 Founded in

Nishitama District, Tokyo is a district located in Tokyo Metropolis, Japan. It comprises the village of Hinohara and the following three towns: * Hinode * Mizuho * Okutama * Historically, the cities of Ōme, Fussa, Hamura, and Akiruno were parts of Nishitama Distr ...

*1957 Authorized as a non-profit research organization under Ministry of Education, Japan *1962

Specific Pathogen Free Specific-pathogen-free (SPF) is a term used for laboratory animals that are guaranteed free of particular pathogens. Use of SPF animals ensures that specified diseases do not interfere with an experiment. For example, absence of respiratory patho ...

(SPF) animal production facility was established in Nogawa, Kawasaki, Japan *1965 Animal production and supply department was spun off as CLEA Japan, Inc. *1966 Preclinical Research Laboratory was established *1969 Germ-free animal facility was established *1973 Bioscience Research Department was established *1976 Organized "The 2nd International Workshop on Nude Mice", Tokyo, Chairman T. Nomura *1979 Appointed as ICLAS Monitoring Center *1982 Embryological Engineering Laboratory was established *1985 Laboratory animal monitoring facilities completed *1987 Developmental Engineering Experiment Manual published *1988 High priority "Laboratory animal monitoring project" started *1991 ''From Six Mice: History of Central Institute for Experimental Animals'' published *1992 Laboratory Animal Cryopreservation Facilities completed *2001 Center for the Advancement of Health and Biosciences (CAHB) established as a nonprofit organization in the United States *2002 Global business development was initiated *2005

patent granted *2006 Tatsuji Nomura becomes chairman of the Board of Directors of CIEA *2006 Organized "The 1st International Workshop on Humanized Mice", Tokyo, Chairman T. Nomura

External links

CIEA websiteMonitoring Center
(Japanese)
International Council for Laboratory Animal Science

References

{{authority control Research institutes in Japan Animal testing