The Center for Molecular and Biomolecular Informatics (CMBI) is an

academic An academy (Attic Greek: Ἀκαδήμεια; Koine Greek Ἀκαδημία) is an institution of tertiary education. The name traces back to Plato's school of philosophy, founded approximately 386 BC at Akademia, a sanctuary of Athena, the go ...

computational biology Computational biology refers to the use of techniques in computer science, data analysis, mathematical modeling and Computer simulation, computational simulations to understand biological systems and relationships. An intersection of computer sci ...

(

bioinformatics Bioinformatics () is an interdisciplinary field of science that develops methods and Bioinformatics software, software tools for understanding biological data, especially when the data sets are large and complex. Bioinformatics uses biology, ...

) research department based in

Nijmegen Nijmegen ( , ; Nijmeegs: ) is the largest city in the Dutch province of Gelderland and the ninth largest of the Netherlands as a whole. Located on the Waal River close to the German border, Nijmegen is one of the oldest cities in the ...

(the

Netherlands , Terminology of the Low Countries, informally Holland, is a country in Northwestern Europe, with Caribbean Netherlands, overseas territories in the Caribbean. It is the largest of the four constituent countries of the Kingdom of the Nether ...

), and is part of the Radboudumc University Medical Center. Most of the research topics at the CMBI focus strongly on (''

in silico In biology and other experimental sciences, an ''in silico'' experiment is one performed on a computer or via computer simulation software. The phrase is pseudo-Latin for 'in silicon' (correct ), referring to silicon in computer chips. It was c ...

'')

biomedical Biomedicine (also referred to as Western medicine, mainstream medicine or conventional medicine)

data analysis of

biomolecule A biomolecule or biological molecule is loosely defined as a molecule produced by a living organism and essential to one or more typically biological processes. Biomolecules include large macromolecules such as proteins, carbohydrates, lipids ...

s, and with - because of the department's embedding in a leading Dutch hospital - a strong interest in medical and clinical

scientific Science is a systematic discipline that builds and organises knowledge in the form of testable hypotheses and predictions about the universe. Modern science is typically divided into twoor threemajor branches: the natural sciences, which stu ...

research lines, both fundamental and translational in nature. Specific topics of interest involve

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...

(structure), (meta)

genomics Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, ...

as well as the analysis of various other types of

omics Omics is the collective characterization and quantification of entire sets of biological molecules and the investigation of how they translate into the structure, function, and dynamics of an organism or group of organisms. The branches of scien ...

data (

transcriptomics Transcriptomics technologies are the techniques used to study an organism's transcriptome, the sum of all of its RNA, RNA transcripts. The information content of an organism is recorded in the DNA of its genome and Gene expression, expressed throu ...

proteomics Proteomics is the large-scale study of proteins. Proteins are vital macromolecules of all living organisms, with many functions such as the formation of structural fibers of muscle tissue, enzymatic digestion of food, or synthesis and replicatio ...

metabolomics Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerpri ...

, amongst others), and small (bio)

molecules A molecule is a group of two or more atoms that are held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemistry ...

and their

drug A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug i ...

, protein or other molecular interaction partners. Furthermore, especially

machine learning Machine learning (ML) is a field of study in artificial intelligence concerned with the development and study of Computational statistics, statistical algorithms that can learn from data and generalise to unseen data, and thus perform Task ( ...

(including the application of

artificial neural networks In machine learning, a neural network (also artificial neural network or neural net, abbreviated ANN or NN) is a computational model inspired by the structure and functions of biological neural networks. A neural network consists of connected ...

), personalized medicine and

FAIR data FAIR data is data which meets the FAIR principles of findability, accessibility, interoperability, and reusability (FAIR). The acronym and principles were defined in a March 2016 paper in the journal '' Scientific Data'' by a consortium of sc ...

research have a lot of interest and attention by the department. As of 2023, the CMBI has become part of the Radboudumc Medical BioSciences department.

History

The institute was founded in 1999 at the

Radboud University Nijmegen Radboud University (abbreviated as RU, , formerly ) is a public university, public research university located in Nijmegen, Netherlands. RU has seven faculties and more than 24,000 students. Established in 1923, Radboud University has consistentl ...

, by the previous department head prof. dr. Gerrit (Gert) Vriend. In 2008 the institute became part of the Radboudumc (i.e. the Radboud University Medical Center). In 2023, the CMBI became part of the Radboudumc Medical BioSciences department.

References

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External links

Radboudumc research website
Bioinformatics organizations Organizations established in 1999 1999 establishments in the Netherlands Radboud University Nijmegen

History

See also

References

External links