Cefonicide (or cefonicid) is a

cephalosporin The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus '' Acremonium'', which was previously known as ''Cephalosporium''. Together with cephamycins, they constitute a subgroup of β-lactam antibioti ...

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy, ...

. It has a density of 1.92g/cm³. __TOC__

Synthesis

Injectable semi-synthetic cephalosporin antibiotic related to

cefamandole Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamand ...

, q.v.

Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2. The mandelic acid amide C-7 side chain is reminiscent of

References

Acetaldehyde dehydrogenase inhibitors Cephalosporin antibiotics Enantiopure drugs Phenylethanolamines Sulfonic acids Tetrazoles {{antibiotic-stub

Synthesis

See also

References