Cefilavancin (TD-1792) is an experimental

antibiotic An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting pathogenic bacteria, bacterial infections, and antibiotic medications are widely used in the therapy ...

medication developed for the treatment of bacterial infections such as drug-resistant strains of ''

Staphylococcus aureus ''Staphylococcus aureus'' is a Gram-positive spherically shaped bacterium, a member of the Bacillota, and is a usual member of the microbiota of the body, frequently found in the upper respiratory tract and on the skin. It is often posi ...

''. It is a

prodrug A prodrug is a pharmacologically inactive medication or compound that, after intake, is metabolized (i.e., converted within the body) into a pharmacologically active drug. Instead of administering a drug directly, a corresponding prodrug can be ...

which is also a

codrug A codrug consists of two drug Moiety (chemistry), moieties, generally "active against the same disease", that are joined through one or more covalent bond, covalent chemical bonds to create a single new chemical entity; they can also be describe ...

, injected intravenously and then cleaved inside the body to two active components, one of which is a modified form of

vancomycin Vancomycin is a glycopeptide antibiotic medication used to treat certain bacterial infections. It is administered intravenously ( injection into a vein) to treat complicated skin infections, bloodstream infections, endocarditis, bone an ...

and the other a

cephalosporin The cephalosporins (sg. ) are a class of β-lactam antibiotics originally derived from the fungus '' Acremonium'', which was previously known as ''Cephalosporium''. Together with cephamycins, they constitute a subgroup of β-lactam antibio ...

antibiotic. In clinical trials cefilavancin has shown similar efficacy with reduced side effects compared to vancomycin itself.

References

{{reflist Antibiotics Heterocyclic compounds with 7 or more rings Carboxamides Amides Chloroarenes Thiazoles Pyridinium compounds Carboxylate anions Zwitterions Polyols Thiazines Azetidines

See also

References