In molecular biology, the Cbl TKB domain (
tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions.
Tyrosine kinases belong to a larger cl ...
binding domain), also known as the
phosphotyrosine
-Tyrosine or tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. The word "tyrosine" is from the G ...
binding (PTB) domain is a conserved region found at the
N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide, referring to the free amine group (-NH2) located at the end of a polypeptide. Within a peptide, the ami ...
of
Cbl CBL may refer to:
CBC Radio
* CBL-FM, a CBC Radio Two radio station in Toronto, Ontario
* CBLA-FM in Toronto had the call sign CBL for much of the period when it was on the AM band (1937–99)
Sports leagues and associations
* Canadian Basebal ...
adaptor proteins. This N-terminal region is composed of three evolutionarily conserved
domains: an N-terminal four-helix bundle domain, an
EF hand
The EF hand is a helix–loop–helix structural domain or ''motif'' found in a large family of calcium-binding proteins.
The EF-hand motif contains a helix–loop–helix topology, much like the spread thumb and forefinger of the human hand, in ...
-like domain and a
SH2-like domain, which together are known to
bind
BIND () is a suite of software for interacting with the Domain Name System (DNS). Its most prominent component, named (pronounced ''name-dee'': , short for ''name daemon''), performs both of the main DNS server roles, acting as an authoritative ...
to
phosphorylated tyrosine residues.
References
{{InterPro content, IPR003153
Protein domains