Catherine Dulac is a French–American

molecular biologist Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...

and

neuroscientist A neuroscientist (or neurobiologist) is a scientist specializing in neuroscience that deals with the anatomy and function of neurons, Biological neural network, neural circuits, and glia, and their Behavior, behavioral, biological, and psycholo ...

. She is a

professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin ...

at the Department of

Molecular A molecule is a group of two or more atoms that are held together by attractive forces known as chemical bonds; depending on context, the term may or may not include ions that satisfy this criterion. In quantum physics, organic chemistry, ...

and Cellular Biology of

Harvard University Harvard University is a Private university, private Ivy League research university in Cambridge, Massachusetts, United States. Founded in 1636 and named for its first benefactor, the History of the Puritans in North America, Puritan clergyma ...

and, since 2022, has been the current Samuel W. Morris University Professor. Prior to her appointment as University Professor, she was the Higgins Professor of Molecular and Cellular Biology (from 2006) and the Lee and Ezpeleta Professor of Arts and Sciences (from 2018) in the Faculty of Arts and Sciences at Harvard University.

Early life and education

Dulac grew up in

Montpellier Montpellier (; ) is a city in southern France near the Mediterranean Sea. One of the largest urban centres in the region of Occitania (administrative region), Occitania, Montpellier is the prefecture of the Departments of France, department of ...

France France, officially the French Republic, is a country located primarily in Western Europe. Overseas France, Its overseas regions and territories include French Guiana in South America, Saint Pierre and Miquelon in the Atlantic Ocean#North Atlan ...

. Her parents were academics and researchers in the

humanities Humanities are academic disciplines that study aspects of human society and culture, including Philosophy, certain fundamental questions asked by humans. During the Renaissance, the term "humanities" referred to the study of classical literature a ...

. She entered the École Normale Supérieure in 1982, graduating with a BSc 4 years later. She then conducted her

PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...

research under Nicole Marthe Le Douarin at the Institut d'Embryologie cellulaire et moléculaire (Institute of Cellular and Molecular Embryology) in

Nogent-sur-Marne Nogent-sur-Marne () is a Communes of France, commune in the eastern suburbs of Paris, France. It is located from the Kilometre Zero, centre of Paris. Nogent-sur-Marne is a ''Subprefectures in France, sous-préfecture'' of the Val-de-Marne ''Depar ...

, which was affiliated to both

Collège de France The (), formerly known as the or as the ''Collège impérial'' founded in 1530 by François I, is a higher education and research establishment () in France. It is located in Paris near La Sorbonne. The has been considered to be France's most ...

and the

French National Centre for Scientific Research The French National Centre for Scientific Research (, , CNRS) is the French state research organisation and is the largest fundamental science agency in Europe. In 2016, it employed 31,637 staff, including 11,137 tenured researchers, 13,415 engi ...

, and defended her PhD

thesis A thesis (: theses), or dissertation (abbreviated diss.), is a document submitted in support of candidature for an academic degree or professional qualification presenting the author's research and findings.International Standard ISO 7144: D ...

at the

Pierre and Marie Curie University Pierre and Marie Curie University ( , UPMC), also known as Paris VI, was a public research university in Paris, France, from 1971 to 2017. The university was located on the Jussieu Campus in the Latin Quarter of the 5th arrondissement of Paris, ...

Paris Paris () is the Capital city, capital and List of communes in France with over 20,000 inhabitants, largest city of France. With an estimated population of 2,048,472 residents in January 2025 in an area of more than , Paris is the List of ci ...

in 1991. She stayed at the Institut d'Embryologie cellulaire et moléculaire until 1992.

Career

After her

, in 1993, Dulac went to

Columbia University Columbia University in the City of New York, commonly referred to as Columbia University, is a Private university, private Ivy League research university in New York City. Established in 1754 as King's College on the grounds of Trinity Churc ...

as a

postdoctoral fellow A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary academ ...

Richard Axel Richard Axel (born July 2, 1946) is an American molecular biologist and university professor in the Department of Neuroscience at Columbia University and investigator at the Howard Hughes Medical Institute. His work on the olfactory system won h ...

's group. One of the reasons for moving to the

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

despite not speaking

English English usually refers to: * English language * English people English may also refer to: Culture, language and peoples * ''English'', an adjective for something of, from, or related to England * ''English'', an Amish ter ...

was her desire to work on

mice A mouse (: mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...

, which was a

model organism A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Mo ...

, unlike

chicken The chicken (''Gallus gallus domesticus'') is a domesticated subspecies of the red junglefowl (''Gallus gallus''), originally native to Southeast Asia. It was first domesticated around 8,000 years ago and is now one of the most common and w ...

embryo An embryo ( ) is the initial stage of development for a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sp ...

s that she had been working on. In 1996, Dulac joined the Department of

and Cellular Biology of

as an

assistant professor Assistant professor is an academic rank just below the rank of an associate professor used in universities or colleges, mainly in the United States, Canada, Japan, and South Korea. Overview This position is generally taken after earning a doct ...

, She was promoted to

associate professor Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. In the ''North American system'', used in the United States and many other countries, it is a position ...

in 2000 and then

full professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a 'person who professes'. Professors ...

in 2001. She was the department chair between 2007 and 2013. Dulac was appointed Higgins Professor of Molecular and Cellular Biology in 2006 and then Lee and Ezpeleta Professor of Arts and Sciences, a five-year position, in 2018. In 2022, she was conferred the highest honor for a Harvard

academic staff Academic staff, also known as faculty (in North American usage) or academics (in British, Australia, and New Zealand usage), are vague terms that describe teachers or research staff of a school, college, university or research institute. In ...

, having been named one of the University Professors, the Samuel W. Morris University Professor. She is also currently a member of the Harvard Brain Science Initiative, as well as the Center for Brain Science and the affiliated Hock E. Tan and K. Lisa Yang Center for Autism Research at Harvard. Dulac has been an investigator at the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization headquartered in Chevy Chase, Maryland with additional facilities in Ashburn, Virginia. It was founded in 1953 by Howard Hughes, an American busin ...

since 1997.

Research

Dulac's research spans from olfactory signalling in

mammal A mammal () is a vertebrate animal of the Class (biology), class Mammalia (). Mammals are characterised by the presence of milk-producing mammary glands for feeding their young, a broad neocortex region of the brain, fur or hair, and three ...

s through

pheromone A pheromone () is a secreted or excreted chemical factor that triggers a social response in members of the same species. Pheromones are chemicals capable of acting like hormones outside the body of the secreting individual, to affect the behavio ...

s to the

neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, ...

sex differences Sexual dimorphism is the condition where sexes of the same species exhibit different morphological characteristics, including characteristics not directly involved in reproduction. The condition occurs in most dioecious species, which consi ...

and parental behaviors. In 1995, working on

, Dulac became the first to identify

gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...

s in mammals that encodes

receptors Receptor may refer to: *Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds ...

for pheromones. These receptors are termed

vomeronasal receptor Vomeronasal receptors are a class of olfactory receptors that putatively function as receptor (biology), receptors for pheromones. Pheromones have evolved in all animal phyla, to signal sex and dominance status, and are responsible for stereotypi ...

s for their presence in a special structure of the

nose A nose is a sensory organ and respiratory structure in vertebrates. It consists of a nasal cavity inside the head, and an external nose on the face. The external nose houses the nostrils, or nares, a pair of tubes providing airflow through the ...

called the

vomeronasal organ The vomeronasal organ (VNO), or Jacobson's organ, is the paired auxiliary olfactory (smell) sense organ located in the soft tissue of the nasal septum, in the nasal cavity just above the roof of the mouth (the hard palate) in various tetrapods ...

(VNO). She continued researching the signalling pathway of pheromone in mice, discovering that Trpc2, an

ion channel Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore. Their functions include establishing a resting membrane potential, shaping action potentials and other electrical signals by Gating (electrophysiol ...

only found in the VNO in mice, played a major role in passing pheromone signals to downstream players in the pheromone signalling pathway. Her group later confirmed the central role Trpc2 plays in mice, showing male mice lacking Trpc2 could not distinguish male mice from female mice, and that female mice lacking Trpc2 sexually behaved more like males. In

human Humans (''Homo sapiens'') or modern humans are the most common and widespread species of primate, and the last surviving species of the genus ''Homo''. They are Hominidae, great apes characterized by their Prehistory of nakedness and clothing ...

s, however, this gene is a

pseudogene Pseudogenes are nonfunctional segments of DNA that resemble functional genes. Pseudogenes can be formed from both protein-coding genes and non-coding genes. In the case of protein-coding genes, most pseudogenes arise as superfluous copies of fun ...

and is non-functional, which partly explains why humans have a less functional pheromone signalling system. Apart from pheromones, Dulac has also studied the regulation of the parental brain, reporting that a group of

neuron A neuron (American English), neurone (British English), or nerve cell, is an membrane potential#Cell excitability, excitable cell (biology), cell that fires electric signals called action potentials across a neural network (biology), neural net ...

s which express

galanin Galanin is a neuropeptide encoded by the ''GAL'' gene, that is widely expressed in the brain, spinal cord, and gut of humans as well as other mammals. Galanin signaling occurs through three G protein-coupled receptors. Much of galanin's functio ...

regulates parental responses in mice. More recently, Dulac began studying a region of the

amygdala The amygdala (; : amygdalae or amygdalas; also '; Latin from Greek language, Greek, , ', 'almond', 'tonsil') is a paired nucleus (neuroanatomy), nuclear complex present in the Cerebral hemisphere, cerebral hemispheres of vertebrates. It is c ...

(known as medial amygdala) and its role in regulating sex-specific behaviors, and entered the field of

epigenetics In biology, epigenetics is the study of changes in gene expression that happen without changes to the DNA sequence. The Greek prefix ''epi-'' (ἐπι- "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in ...

, for example profiling

genomic imprinting Genomic imprinting is an epigenetic phenomenon that causes genes to be expressed or not, depending on whether they are inherited from the female or male parent. Genes can also be partially imprinted. Partial imprinting occurs when alleles from b ...

in mice.

Awards and honors

Searle Scholar The Searle Scholars Program is a career development award made annually to support 15 young faculty in biomedical research and chemistry at US universities and research centers. The goal of the award is to support to exceptional young scientists wh ...

(1998) * Member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

(2004) *

Richard Lounsbery Award The Richard Lounsbery Award is given to American and French scientists, 45 years or younger, in recognition of "extraordinary scientific achievement in biology and medicine." The Award alternates between French and American scientists, and is a ...

(2006) * Member of the

French Academy of Sciences The French Academy of Sciences (, ) is a learned society, founded in 1666 by Louis XIV at the suggestion of Jean-Baptiste Colbert, to encourage and protect the spirit of French Scientific method, scientific research. It was at the forefron ...

(2007) * Perl-UNC Neuroscience Prize (2010) * Knight of

National Order of the Legion of Honour The National Order of the Legion of Honour ( ), formerly the Imperial Order of the Legion of Honour (), is the highest and most prestigious French national order of merit, both military and civil. Currently consisting of five classes, it was ...

(2011) *

Member Member may refer to: * Military jury, referred to as "Members" in military jargon * Element (mathematics), an object that belongs to a mathematical set * In object-oriented programming, a member of a class ** Field (computer science), entries in ...

of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, NGO, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the ...

(2015) * Edward M. Scolnick Prize in Neuroscience,

McGovern Institute for Brain Research The McGovern Institute for Brain Research is a research institute within MIT. Its mission is to understand how the brain works and to discover new ways to prevent or treat brain disorders. The institute was founded in 2000 by Patrick McGovern ...

(2015) *

Karl Spencer Lashley Award The Karl Spencer Lashley Award is awarded by The American Philosophical Society as a recognition of research on the integrative neuroscience of behavior. The award was established in 1957 by a gift from Dr. Karl Spencer Lashley. Recipients * 20 ...

(2018) * Member of the

American Philosophical Society The American Philosophical Society (APS) is an American scholarly organization and learned society founded in 1743 in Philadelphia that promotes knowledge in the humanities and natural sciences through research, professional meetings, publicat ...

(2019) * Ralph W. Gerard Prize in Neuroscience (2019) *

Breakthrough Prize in Life Sciences The Breakthrough Prize in Life Sciences is a scientific award, funded by internet entrepreneurs Mark Zuckerberg and Priscilla Chan of Facebook; Sergey Brin of Google; entrepreneur and venture capitalist Yuri Milner; and Anne Wojcicki, one of t ...

(2021) * Officer of the National Order of the Legion of Honour (2022)

References

{{DEFAULTSORT:Dulac, Catherine 1963 births Living people 21st-century American biologists Howard Hughes Medical Investigators École Normale Supérieure alumni Pierre and Marie Curie University alumni Columbia University fellows Harvard University faculty Fellows of the American Academy of Arts and Sciences Searle Scholars Program recipients Members of the French Academy of Sciences American women biologists Members of the American Philosophical Society Members of the United States National Academy of Sciences Richard-Lounsbery Award laureates Officers of the Legion of Honour American neuroscientists American women neuroscientists American women academics French emigrants to the United States 21st-century American women scientists