A cartwheel pattern is a histopathologic architectural pattern. Microscopically, cartwheel arrangements appear to have center points that radiate cells or

connective tissue Connective tissue is one of the four primary types of animal tissue, a group of cells that are similar in structure, along with epithelial tissue, muscle tissue, and nervous tissue. It develops mostly from the mesenchyme, derived from the mesod ...

outward. Cartwheel patterns may be irregular and, at lower magnification, can cause tissue to appear tangled into clumps. Skin tumors that can be classified as "storiform," having spindle cells with elongated nuclei radiating from a center point, are mainly: * Fibrous histiocytoma (dermatofibroma) *Soft tissue perineurioma *

Dermatofibrosarcoma protuberans Dermatofibrosarcoma protuberans (DFSP) is a rare locally aggressive malignant cutaneous soft-tissue sarcoma. DFSP develops in the connective tissue cells in the middle layer of the skin (dermis). Estimates of the overall occurrence of DFSP in the U ...

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{{Pathology-stub Histopathology