Captopril Challenge Test
   HOME

TheInfoList



Click Here for Items Related To - Captopril Challenge Test
OR:
Captopril Challenge Test on:   [Wikipedia]   [Google]   [Amazon]

__NOTOC__ The captopril challenge test (CCT) is a non-invasive medical test that measures the change in
renin Renin ( etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin-angiotensin-aldosterone system (RAAS)—also known as the reni ...
plasma-levels in response to administration of
captopril Captopril, sold under the brand name Capoten among others, is an ACE inhibitor, angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure. Captopril was the first oral ACE inh ...
, an
angiotensin converting enzyme inhibitor Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of hypertension, high blood pressure and heart failure. This class of medicine works by causing relaxation of blood vessels as ...
. It is used to assist in the diagnosis of
renal artery stenosis Renal artery stenosis (RAS) is the narrowing of one or both of the renal arteries, most often caused by atherosclerosis or fibromuscular dysplasia. This narrowing of the renal artery can impede blood flow to the target kidney, resulting in r ...
. It is not generally considered a useful test for children, and more suitable options are available for adult cases.


Procedure

Plasma concentration of renin is measured prior to and following the administration of captopril. The CCT is considered positive if the renin levels increase substantially or the baseline renin level is abnormally high.


In adults

CCT in adults is known to have high sensitivity, but a low specificity. Subtraction angiography is considered a more suitable test for renal artery stenosis in adults.


See also

*
Captopril suppression test The captopril suppression test (CST) is a non-invasive medical test that measures plasma levels of aldosterone. Aldosterone production is suppressed by captopril through the renin–angiotensin–aldosterone system. CST results are used to assi ...
- used to diagnose
primary aldosteronism Primary aldosteronism (PA)'','' also known as primary hyperaldosteronism, refers to the excess production of the hormone aldosterone from the adrenal glands, resulting in low renin levels and high blood pressure. This abnormality is a paraneopl ...


References

{{Endocrine system procedures Blood tests Dynamic endocrine function tests