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A cannabis edible, also known as a cannabis-infused food or simply an edible, is a food item (either homemade or produced commercially) that contains decarboxylated cannabinoids (cannabinoid acids converted to their orally bioactive form) from cannabis extract as an
active ingredient An active ingredient is any ingredient that provides biologically active or other direct effect in the diagnosis, cure, mitigation, treatment, or prevention of disease or to affect the structure or any function of the body of humans or animals. ...
. Although ''edible'' may refer to either a food or a drink, a cannabis-infused drink may be referred to more specifically as a liquid edible or drinkable. Edibles are a way to consume cannabis. Unlike smoking, in which cannabinoids are inhaled into the lungs and pass rapidly into the bloodstream, peaking in about ten minutes and wearing off in a couple of hours, cannabis edibles may take hours to digest, and their effects may peak two to three hours after consumption and persist for around six hours. The food or drink used may affect both the timing and potency of the dose ingested. Most edibles contain a significant amount of THC, which can induce a wide range of effects, including: heightened sensory perception, relaxation,
sleepiness Somnolence (alternatively sleepiness or drowsiness) is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia). It has distinct meanings and causes. It can refer to the usual state preceding falling asleep ...
,
dizziness Dizziness is an imprecise term that can refer to a sense of disorientation in space, vertigo, or lightheadedness. It can also refer to Balance disorder, disequilibrium or a non-specific feeling, such as giddiness or foolishness. Dizziness is a ...
,
dry mouth Xerostomia, also known as dry mouth, is a subjective complaint of dryness in the mouth, which may be associated with a change in the composition of saliva, reduced salivary flow, or have no identifiable cause. This symptom is very common and is o ...
,
euphoria Euphoria ( ) is the experience (or affect) of pleasure or excitement and intense feelings of well-being and happiness. Certain natural rewards and social activities, such as aerobic exercise, laughter, listening to or making music and da ...
,
depersonalization Depersonalization is a dissociative phenomenon characterized by a subjective feeling of detachment from oneself, manifesting as a sense of disconnection from one's thoughts, emotions, sensations, or actions, and often accompanied by a feeling of ...
and/or
derealization Derealization is an alteration in the perception of the external world, causing those with the condition to perceive it as unreal, distant, distorted, or in other ways falsified. Other symptoms include feeling as if one's environment lacks spontan ...
,
hallucination A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality. They are distinguishable from several related phenomena, such as dreaming ( REM sleep), which does not involve wakefulness; pse ...
s,
paranoia Paranoia is an instinct or thought process that is believed to be heavily influenced by anxiety, suspicion, or fear, often to the point of delusion and irrationality. Paranoid thinking typically includes persecutory beliefs, or beliefs of co ...
, and decreased or increased
anxiety Anxiety is an emotion characterised by an unpleasant state of inner wikt:turmoil, turmoil and includes feelings of dread over Anticipation, anticipated events. Anxiety is different from fear in that fear is defined as the emotional response ...
. THC-dominant edibles are consumed for
recreational Recreation is an activity of leisure, leisure being discretionary time. The "need to do something for recreation" is an essential element of human biology and psychology. Recreational activities are often done for enjoyment, amusement, or plea ...
and medical purposes. Some edibles contain a negligible amount of THC and are instead dominant in other cannabinoids, most commonly
cannabidiol Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in ''Cannabis'', along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. Medically, it is an anticonvulsant used to treat multiple f ...
(CBD). The main characteristic of cannabis edibles is that they take longer to affect users compared to smoked cannabis. Foods and beverages made from non-psychoactive cannabis products are known as hemp foods.


History


Eastern

The earliest mention of cannabis-infused food was as far back as 2000 B.C. in
India India, officially the Republic of India, is a country in South Asia. It is the List of countries and dependencies by area, seventh-largest country by area; the List of countries by population (United Nations), most populous country since ...
. Known as one of the oldest cannabis traditions,
Bhang Bhang (International Alphabet of Sanskrit Transliteration, IAST: ''Bhāṅg'') is an Cannabis edible, edible preparation made from the leaves of the Cannabis (drug), cannabis plant originating from the Indian subcontinent. ''Cannabis sativa'' ...
– a cannabis infused drink made with yogurt, nuts, spices, rose water – is an official drink of
Holi Holi () is a major Hindu festival celebrated as the Festival of Colours, Love and Spring.The New Oxford Dictionary of English (1998) p. 874 "Holi /'həʊli:/ noun a Hindu spring festival ...".Yudit Greenberg, Encyclopedia of Love in World ...
, highly celebrated and revered festivals celebrated by the people of
Hindu Hindus (; ; also known as Sanātanīs) are people who religiously adhere to Hinduism, also known by its endonym Sanātana Dharma. Jeffery D. Long (2007), A Vision for Hinduism, IB Tauris, , pp. 35–37 Historically, the term has also be ...
community in India revering
Shiva Shiva (; , ), also known as Mahadeva (; , , Help:IPA/Sanskrit, ɐɦaːd̪eːʋɐh and Hara, is one of the Hindu deities, principal deities of Hinduism. He is the God in Hinduism, Supreme Being in Shaivism, one of the major traditions w ...
or
Kali Kali (; , ), also called Kalika, is a major goddess in Hinduism, primarily associated with time, death and destruction. Kali is also connected with transcendental knowledge and is the first of the ten Mahavidyas, a group of goddesses who p ...
. The oil-solubility of cannabis extracts was also known to ancient Indians, with
Sanskrit Sanskrit (; stem form ; nominal singular , ,) is a classical language belonging to the Indo-Aryan languages, Indo-Aryan branch of the Indo-European languages. It arose in northwest South Asia after its predecessor languages had Trans-cultural ...
recipes requiring cannabis to be sautéed in
ghee Ghee is a type of clarified butter, originating from South Asia. It is commonly used for cooking, as a Traditional medicine of India, traditional medicine, and for Hinduism, Hindu religious rituals. Description Ghee is typically prepared by ...
before mixing it with other ingredients.
Majoun Majoun or majun ( , " kneaded"/"paste") is a Moroccan confection, which can resemble a pastry ball, fudge, or jam. Ingredients can include honey, nuts, and dried fruits, and the treat is commonly made as a cannabis edible, sometimes in combinatio ...
(cannabis jam) is another early type of edible first created by the nomadic
Berber tribes Berber tribes are tribes of Berbers, Berber descent inhabiting the Maghreb region. They are traditionally divided into three large tribal confederations: Masmuda, Zenata and Sanhaja., They often form smaller confederations of tribes together (for e ...
of North Africa sometime around the 11th century. The traditional Majoun recipe calls for cannabis extract,
datura ''Datura'' is a genus of nine species of highly poisonous, Vespertine (biology), vespertine-flowering plants belonging to the nightshade family (Solanaceae). They are commonly known as thornapples or jimsonweeds, but are also known as devil's t ...
seeds, honey, nuts, kif (a mixture of kief), and sometimes dates and figs.


Western

The first mention of edibles in Europe appeared in a cookbook titled ''
De honesta voluptate et valetudine ''De honesta voluptate et valetudine'' (, often shortened to ''De honesta voluptate'') was the first cookbook ever printed. Written by Bartolomeo Platina; it first appeared between 1470 and 1475 in Rome, and in 1475 in Venice. Written in Latin ...
'', which translates to "On Honorable Pleasure and Health" written by
Bartolomeo Platina Bartolomeo Sacchi (; 1421 – 21 September 1481), known as il Platina () after his birthplace of Piadena, was an Italian Renaissance humanist writer and gastronomist, author of what is considered the first printed cookbook. Platina star ...
in 1465. The first cannabis edible recipe appeared in the United States in the early 1960s in a cookbook called '' The Alice B. Toklas Cook Book'' written by
Alice B. Toklas Alice Babette Toklas (April 30, 1877 – March 7, 1967) was an American-born member of the Parisian avant-garde of the early 20th century, and the life partner of American writer Gertrude Stein. Early life Alice B. Toklas was born in San F ...
. The recipe is called "Hashish Fudge" and was actually contributed by Alice's good friend,
Brion Gysin Brion Gysin (19 January 1916 – 13 July 1986) was a British-Canadian painter, writer, sound poet, performance artist and inventor of experimental devices. He is best known for his use of the cut-up technique, alongside his close friend, the ...
. Although it was omitted from the first American editions, Toklas' name and her "brownies" became synonymous with cannabis in the growing
1960s counterculture The counterculture of the 1960s was an anti-establishment cultural phenomenon and political movement that developed in the Western world during the mid-20th century. It began in the early 1960s, and continued through the early 1970s. It is oft ...
. Since then, many more cannabis cookbooks have been published. In some U.S. states that have legalized cannabis, edibles have experienced a dramatic rise in sales. Since edibles often look like regular candy, they can be mistakenly eaten by children. Between 2009 and 2015 after cannabis was legalised in Colorado, there was a five-fold increase in the number of children under 10 who were treated in hospital or poison center for exposure to cannabis. Edibles were implicated in over half of these. Variations in dosage and delay in onset of effects (leading to taking of additional doses) also can cause overdose especially in children and inexperienced users. Calls to
poison control A poison control center is a medical service that is able to provide immediate, free, and expert treatment advice and assistance over the telephone in case of exposure to poisonous or hazardous substances. Poison control centers answer questions ...
have dramatically increased since 2008 due to dogs ingesting edibles. In Canada, cannabis-infused food products were legalized in October 2018, but regulatory restrictions and reduced consumer interest may inhibit innovation.


Chemistry


Effects

Ingesting cannabis may produce effects that last longer and can be more intense than inhaling cannabis. Different edible formats of cannabinoids may affect the rate of cannabinoid digestion and metabolism, which vary among people. Generally, edible cannabis products are digested more slowly than occurs for
aerosol An aerosol is a suspension (chemistry), suspension of fine solid particles or liquid Drop (liquid), droplets in air or another gas. Aerosols can be generated from natural or Human impact on the environment, human causes. The term ''aerosol'' co ...
products. Oral administration generally leads to two peaks of concentration, due to
enterohepatic circulation Enterohepatic circulation is the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver. Enterohepa ...
. Common
side effect In medicine, a side effect is an effect of the use of a medicinal drug or other treatment, usually adverse but sometimes beneficial, that is unintended. Herbal and traditional medicines also have side effects. A drug or procedure usually use ...
s of ingesting edibles include increased appetite, dry mouth, and bloodshot eyes.


Possible health effects

Cannabis edibles contain both delta 9 THC, which is responsible for the psychotropic properties of feeling relaxed and euphoric, and CBD, which may have effects without the psychoactive properties. Such effects may include
analgesia Pain management is an aspect of medicine and health care involving relief of pain (pain relief, analgesia, pain control) in various dimensions, from acute and simple to chronic and challenging. Most physicians and other health professionals ...
, decreased
inflammation Inflammation (from ) is part of the biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin ''calor'', '' ...
, decreased
spasticity Spasticity () is a feature of altered skeletal muscle performance with a combination of paralysis, increased tendon reflex activity, and hypertonia. It is also colloquially referred to as an unusual "tightness", stiffness, or "pull" of muscles. ...
, and anti-seizure effects. Cannabis edibles with CBD can decrease symptoms of psychosis and anxiety. Edible oils, tinctures, pills, and gummies have been prescribed to people with cancer to potentially improve poor appetite, pain, or weight loss. Cannabis edibles may be effective for
muscle spasm A spasm is a sudden involuntary contraction of a muscle, a group of muscles, or a hollow organ, such as the bladder. A spasmodic muscle contraction may be caused by many medical conditions, including dystonia. Most commonly, it is a musc ...
s and pain.


Possible side effects

Some users of cannabis have reported adverse effects, such as
confusion In psychology, confusion is the quality or emotional state of being bewildered or unclear. The term "acute mental confusion"
,
hallucination A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality. They are distinguishable from several related phenomena, such as dreaming ( REM sleep), which does not involve wakefulness; pse ...
s,
panic attack Panic attacks are sudden periods of intense fear and Comfort, discomfort that may include palpitations, otherwise defined as a Tachycardia, rapid, Arrhythmia, irregular Heart rate, heartbeat, Hyperhidrosis, sweating, chest pain or discomfort, s ...
s,
paranoia Paranoia is an instinct or thought process that is believed to be heavily influenced by anxiety, suspicion, or fear, often to the point of delusion and irrationality. Paranoid thinking typically includes persecutory beliefs, or beliefs of co ...
, and intense psychotic effects. Cannabis may cause short-term impairments in cognition, memory, alertness, coordination, and balance which can increase risk of falls, especially in older people, and make driving a car dangerous. Overdoses may occur because the dosage of THC in edibles is impossible to determine without specialized lab equipment and it varies from product to product. Some or all legalized U.S. states require packaged edibles to have dosage on the label; for instance California AB266 requires labeling to include "THC and other cannabinoid amount in milligrams per serving, servings per package, and the THC and other cannabinoid amount in milligrams for the package total", and states have required the recall of incorrectly labeled products. Overdoses can cause behavioral impairments, such as
paranoia Paranoia is an instinct or thought process that is believed to be heavily influenced by anxiety, suspicion, or fear, often to the point of delusion and irrationality. Paranoid thinking typically includes persecutory beliefs, or beliefs of co ...
, impaired mobility, and
nausea Nausea is a diffuse sensation of unease and discomfort, sometimes perceived as an urge to vomit. It can be a debilitating symptom if prolonged and has been described as placing discomfort on the chest, abdomen, or back of the throat. Over 30 d ...
. Other risks, as a result of regular long-term cannabis use, include harmful effects to brain development, heart function, memory and cognition, and psychiatric health. Long-term recreational marijuana use can cause cognitive impairments and also lead to
cannabis use disorder Cannabis use disorder (CUD), also known as cannabis addiction or marijuana addiction, is a psychiatric disorder defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders ( DSM-5) and ICD-10 as the continued us ...
(CUD). Symptoms of CUD include lack of motivation, decreased concentration, and loss of interest in other activities, tolerance, and dependence.


Types


Edible infusions


Food

The important base to all food edibles is that it has fat that has been infused with THC. In other words, any food that contains butter, oil, milk, or any fatty substance can be turned into an edible. Examples of cannabis-infused foods include baked goods, candy, potato chips, and more. One may not be able to distinguish between regular baked goods and those containing cannabinoids. A mild grassy or cannabis flavor might be detectable if sufficient cannabis quantities are used. Dawamesc is a cannabis edible found in Algeria and some other Arab countries, made of cannabis tops combined with: "sugar, orange juice, cinnamon, cloves, cardamom, nutmeg, musk, pistachios, and pine nuts." Happy pizza is a style of
pizza Pizza is an Italian cuisine, Italian, specifically Neapolitan cuisine, Neapolitan, dish typically consisting of a flat base of Leavening agent, leavened wheat-based dough topped with tomato, cheese, and other ingredients, baked at a high t ...
in
Cambodia Cambodia, officially the Kingdom of Cambodia, is a country in Southeast Asia on the Mainland Southeast Asia, Indochinese Peninsula. It is bordered by Thailand to the northwest, Laos to the north, and Vietnam to the east, and has a coastline ...
which includes cannabis-infused ingredients and has enough THC for psychoactive effects. Cannabis-infused brownies contain
cocoa solids Dry cocoa solids are the components of cocoa beans remaining after cocoa butter, the fatty component of the bean, is extracted from chocolate liquor, roasted cocoa beans that have been ground into a liquid state. Cocoa butter is 46% to 57% of th ...
which forms a polysubstance combination.


Drink

A cannabis-infused drink is a drink infused with THC and can be as potent as a cannabis-infused food. In U.S. states that have legalized cannabis for recreational use, drinks were about 4% of the cannabis market in 2014 but had fallen to around 1.5% of the market in 2016. Cannabis infused drinks can come in the form of coffee, tea, soda, and
alcohol Alcohol may refer to: Common uses * Alcohol (chemistry), a class of compounds * Ethanol, one of several alcohols, commonly known as alcohol in everyday life ** Alcohol (drug), intoxicant found in alcoholic beverages ** Alcoholic beverage, an alco ...
. THC-infused
seltzer Carbonated water is water containing dissolved carbon dioxide gas, either artificially injected under pressure, or occurring due to natural geological processes. Carbonation causes small bubbles to form, giving the water an effervescence, effer ...
s, a rapidly growing category of cannabis beverages, are becoming increasingly popular as an alternative to alcohol. List: *
Bhang Bhang (International Alphabet of Sanskrit Transliteration, IAST: ''Bhāṅg'') is an Cannabis edible, edible preparation made from the leaves of the Cannabis (drug), cannabis plant originating from the Indian subcontinent. ''Cannabis sativa'' ...
* Cannabis tea * Maltos-Cannabis * Pabst Blue Ribbon THC-infused seltzer


= Tincture

= According to the European Medicines Agency (EMA) cannabis tinctures (''tincturea'') are a type of liquid cannabis extract obtained using
ethanol Ethanol (also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound with the chemical formula . It is an Alcohol (chemistry), alcohol, with its formula also written as , or EtOH, where Et is the ps ...
,
water Water is an inorganic compound with the chemical formula . It is a transparent, tasteless, odorless, and Color of water, nearly colorless chemical substance. It is the main constituent of Earth's hydrosphere and the fluids of all known liv ...
,
glycerol Glycerol () is a simple triol compound. It is a colorless, odorless, sweet-tasting, viscous liquid. The glycerol backbone is found in lipids known as glycerides. It is also widely used as a sweetener in the food industry and as a humectant in pha ...
,
propylene glycol Propylene glycol ( IUPAC name: propane-1,2-diol) is a viscous, colorless liquid. It is almost odorless and has a faintly sweet taste. Its chemical formula is CH3CH(OH)CH2OH. As it contains two alcohol groups, it is classified as a diol. An al ...
and fatty oils as extraction solvents, depending on the type of tincture (and also on the solvent used) it can have a specific mass/volume ratio or a specific
therapeutic agents Medication (also called medicament, medicine, pharmaceutical drug, medicinal product, medicinal drug or simply drug) is a drug used to diagnose, cure, treat, or prevent disease. Drug therapy (pharmacotherapy) is an important part of the m ...
content. Tinctures are potent, alcohol-based cannabis extracts. The solubility of THC in ethanol is greater than 1 g/mL. They are considered edibles as they are meant to be absorbed through the mouth and tongue. Tinctures are generally placed under the tongue using a dropper to allow it to be absorbed into the bloodstream. Tinctures can be added to any food or drink and provides more control over the cannabis dosage compared to cannabis-infused foods or drinks.


Dissolvable cannabinoid powder

Dissolvable cannabinoid powder is tasteless and odorless, and may elicit effects typical of oral cannabis products. Powders are water-soluble and can be mixed into foods and drinks. Unlike traditional edibles which can take some 90 minutes to take effect, cannabinoid powder may produce effects within 20 minutes due to solubility and uptake of the powder constituents via the digestive tract, allowing rapid effects, especially of THC.


CBD edibles

Cannabidiol Cannabidiol (CBD) is a phytocannabinoid, one of 113 identified cannabinoids in ''Cannabis'', along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. Medically, it is an anticonvulsant used to treat multiple f ...
(CBD) edibles are non-psychoactive and non-intoxicating, and contain varying amounts of THC, according to the manufacturer. These edibles provide the effects of cannabis without the psychoactive response to THC.


Capsule

Cannabis capsules are considered edibles as they are also metabolized in the gut. Capsules can contain either THC or CBD and are an easier, more convenient way of administering products.


Ingredients


Oil

Cannabis oil, or canna-oil, is a product that combines oil with THC. This combination is achieved through a process of infusion, where the THC is extracted from the flowers or concentrates and then added to the oil. The resulting product is a liquid that can be consumed orally, used as a cooking ingredient, or applied topically. Coconut oil is a commonly used oil for infusion, but other options are olive, avocado, and walnut oil.


Butter

Cannabis butter, or cannabutter, is unsalted butter blended with cannabis and water. Cleaned and dried buds are steeped in melted butter or oil in preparation for consumption. Cannabutter can be added to any baking recipe.


Safety


Physical

The adverse effects on health are most important when it is used in excessive quantities or with heavy frequency. A study funded by the
National Institute on Drug Abuse The National Institute on Drug Abuse (NIDA) is a United States federal government research institute whose mission is to "advance science on the causes and consequences of drug use and addiction and to apply that knowledge to improve individual ...
entitled "Tasty THC: Promises and Challenges of Cannabis Edibles" found that heavy, long-term cannabis use appeared to worsen brain development, and psychiatric and heart health. On the other hand, the study also discovered that cannabis edibles did not appear to affect pulmonary function nor increase risk for cancer which is one reason people choose cannabis edibles over smoking cannabis. The study concedes that over-consuming cannabis is not lethal; to date, there has never been a death related to the actual toxicity of cannabis. However, there has been one death involving cannabis edibles. A safety concern with regards to cannabis edibles is overconsumption which is usually caused by the delayed effects of ingested cannabis. Because users do not feel the effects of cannabis edibles immediately, users may eat more to compensate and end up consuming too much THC. As a result, cannabis edibles as such have caused the most healthcare visits as compared to other forms of cannabis consumption. (Additionally, the amount of THC in any individual product may be highly variable.) Additionally people can have very different responses to the same amount of THC with 2.5 mg being enough for some people to begin to feel effects whilst, for others, 50 mg is required. Thus typical advice for newcomers is to "start low and go slow" in order to gauge the over-all initial effects, with 5–10 mg being one neophyte range.


Psychological

High concentrations of THC have been shown to cause
hallucination A hallucination is a perception in the absence of an external stimulus that has the compelling sense of reality. They are distinguishable from several related phenomena, such as dreaming ( REM sleep), which does not involve wakefulness; pse ...
s, delusions, and anxiety in some people; for most, these symptoms only last as long as that person is intoxicated, but some people can be affected for several days. Cannabis use has been connected with increased use of other drugs, although this connection has never been shown to be causal.


Children

Many edible cannabis products are packaged in a way which could appeal to children (gummies, etc.), though laws requiring a minimum age to purchase recreational cannabis are universal in jurisdictions that have fully legalized its use, similar to age restrictions on alcohol. As with alcohol and prescription medicines, care should be taken to prevent children from having access to the product, as cannabis edibles have been the main cause of a number of health care visits relating to accidental cannabis consumption by children. In 2022, the US National Poison Data System reported about 6,000 people calling for help after children under the age of 13 ate cannabis edibles, compared to 1,800 calls for CBD and 2,000 for dried marijuana. Children under the age of 5 who ate cannabis edibles is the largest source of marijuana-related calls to poison centers (36% of calls about marijuana product exposures in 2021). Although 65% of calls about a child under 13 who had consumed edibles ultimately involved no or only minor effects, almost 3% involved a child who was experiencing life-threatening symptoms or a similar major effect from consumption of the edibles. About 60% of these calls resulted in medical evaluation, and 20% resulted in
hospitalization A hospital is a healthcare institution providing patient treatment with specialized health science and auxiliary healthcare staff and medical equipment. The best-known type of hospital is the general hospital, which typically has an emergency ...
. Cannabis intoxication in children under 10 is primarily due to unintentional intoxication through cannabis edibles, such as a child eating what appears to be candy. In such cases, it is typically the only drug consumed by the child, and is much more likely to result in hospitalization than in teenagers. , many children have needed care in an
intensive care unit An intensive care unit (ICU), also known as an intensive therapy unit or intensive treatment unit (ITU) or critical care unit (CCU), is a special department of a hospital or health care facility that provides intensive care medicine. An inten ...
, including
intubation Intubation (sometimes entubation) is a medical procedure involving the insertion of a tube into the body. Most commonly, intubation refers to tracheal intubation, a procedure during which an endotracheal tube is inserted into the trachea to supp ...
. Although deaths and other serious outcomes are "rarely reported", at least one child has died from eating THC gummies.


See also

* Brownie Mary * Chef Ra * Mushroom edible


References


External links


Beyond brownies: Cannabis chefs elevate edibles recipes
San Francisco Chronicle. 2018-10-09. {{Cannabis Cannabis culture