Cannabipiperidiethanone (CPE or 1-(N-methylpiperidin-2-ylmethyl)-3-(2-methoxyphenylacetyl)indole) is a

synthetic cannabinoid Synthetic cannabinoids, or neocannabinoids, are a class of designer drug molecules that Binding affinity, bind to the same receptors to which cannabinoids (Tetrahydrocannabinol, THC, Cannabidiol, CBD and many others) in cannabis plants attach. Th ...

that has been found to be an ingredient of "herbal smoking blends" sold in

Japan Japan is an island country in East Asia. Located in the Pacific Ocean off the northeast coast of the Asia, Asian mainland, it is bordered on the west by the Sea of Japan and extends from the Sea of Okhotsk in the north to the East China Sea ...

. The drug's binding affinity was measured at the CB₁ and CB₂ receptors and it was found to have an IC₅₀ of 591 nM at CB₁ and 968 nM at CB₂, making it 2.3 times and 9.4 times weaker than

JWH-250 JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the Cannabinoid receptor 1, CB1 and Cannabinoid receptor 2 (macrophage), CB2 receptors, w ...

at these two targets respectively. In the

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

, CB₁ receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are

Schedule I Controlled Substance The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and distribution of certain substances is regulated. It was passed by the 91st United State ...

References

Aminoalkylindoles Piperidines Phenylacetylindoles CB1 receptor agonists CB2 receptor agonists {{cannabinoid-stub

See also

References