Call–Exner bodies, giving a follicle-like appearance, are small

eosinophilic Eosinophilic (Greek suffix -phil-, meaning ''loves eosin'') is the staining of tissues, cells, or organelles after they have been washed with eosin, a dye. Eosin is an acidic dye for staining cell cytoplasm, collagen, and muscle fibers. ''E ...

fluid-filled punched out spaces between

granulosa cell A granulosa cell or follicular cell is a somatic cell of the sex cord that is closely associated with the developing female gamete (called an oocyte or egg) in the ovary of mammals. Structure and function In the primordial ovarian follicle, and ...

s. The granulosa cells are usually arranged haphazardly around the space. They are

pathognomonic Pathognomonic (rare synonym ''pathognomic'') is a term, often used in medicine, that means "characteristic for a particular disease". A pathognomonic sign is a particular sign whose presence means that a particular disease is present beyond any dou ...

for granulosa cell tumors. Histologically, these tumors consists of monotonous islands of granulosa cells with "coffee-bean" nuclei. That same nuclear groove appearance noted in

Brenner tumour Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are benign, but some can be malignant. They are most frequently found incidentally on pelvic examination A pelvic examinati ...

, an epithelial-stromal ovarian tumor distinguishable by nests of transitional epithelial cells (urothelial) with longitudinal nuclear grooves (coffee bean nuclei) in abundant fibrous stroma. They are composed of membrane-packaged secretion of granulosa cells and have relations to the formation of liquor folliculi which are seen among closely arranged granulosa cells. They are named for Emma Louise Call (1847–1937), an American physician, and

Sigmund Exner Sigmund Exner (also ''Sigmund Exner'', ''Siegmund Exner-Ewarten'', ''Siegmund Exner Ritter von Ewarten''; 5 April 1846 – 5 February 1926) was an Austrian physiologist born in Vienna. Academic career He studied in Vienna under Ernst Wilhelm ...

(1846-1926), an Austrian physiologist.Emma Louise Call and Sigmund Exner: ''Zur Kenntniss des Graafschen Follikels und des Corpus luteum beim Kaninchen.'' Sitzungsberichte der kaiserlichen Akademie der Wissenschaften. Mathematish naturwssenschaftliche Classe, Wien, 1875, 72: 321-328.

References

External links

WebPathology
Histopathology {{pathology-stub