Cyp6g1 or DDT-R is an insecticide resistance gene for resistance to DDT in ''

Drosophila melanogaster ''Drosophila melanogaster'' is a species of fly (the taxonomic order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the " vinegar fly" or " pomace fly". Starting with ...

''. It belongs to the

cytochrome P450 family Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that functions as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compo ...

and is located in chromosome 2R. Following up their earlier work, Daborn et al 2002 find the DDT-R gene induces over

transcription Transcription refers to the process of converting sounds (voice, music etc.) into letters or musical notes, or producing a copy of something in another medium, including: Genetics * Transcription (biology), the copying of DNA into RNA, the fir ...

of Cyp6g1, of which there are 4 duplicates. They also find several substrates of Cyp6g1, namely DDT,

lufenuron Lufenuron is the active ingredient in the veterinary flea control medication Program, and one of the two active ingredients in the flea, heartworm, ringworm and anthelmintic medicine milbemycin oxime/lufenuron (Sentinel). Lufenuron is stored in ...

, and

nitenpyram Nitenpyram is a chemical frequently used as an insecticide in agriculture and veterinary medicine. The compound is an insect neurotoxin belonging to the class of neonicotinoids which works by blocking neural signaling of the central nervous syst ...

References

External links

FlyBase Gene Report: Dmel\Cyp6g1
at

FlyBase FlyBase is an online bioinformatics database and the primary repository of genetic and molecular data for the insect family Drosophilidae. For the most extensively studied species and model organism, ''Drosophila melanogaster'', a wide range of d ...

database of Drosophila genes. {{Cytochrome P450 6 Drosophila melanogaster genes DDT EC 1.14