Cytochrome P450, family 27, also known as CYP27, is a

Deuterostome Deuterostomes (from Greek: ) are bilaterian animals of the superphylum Deuterostomia (), typically characterized by their anus forming before the mouth during embryonic development. Deuterostomia comprises three phyla: Chordata, Echinodermata, ...

cytochrome P450 Cytochromes P450 (P450s or CYPs) are a Protein superfamily, superfamily of enzymes containing heme as a cofactor (biochemistry), cofactor that mostly, but not exclusively, function as monooxygenases. However, they are not omnipresent; for examp ...

monooxygenase Monooxygenases are enzymes that incorporate one hydroxyl group (−OH) into substrates in many metabolic pathways. In this reaction, the two atoms of dioxygen are reduced to one hydroxyl group and one H2O molecule by the concomitant oxidation of ...

family Family (from ) is a Social group, group of people related either by consanguinity (by recognized birth) or Affinity (law), affinity (by marriage or other relationship). It forms the basis for social order. Ideally, families offer predictabili ...

found in

human genome The human genome is a complete set of nucleic acid sequences for humans, encoded as the DNA within each of the 23 distinct chromosomes in the cell nucleus. A small DNA molecule is found within individual Mitochondrial DNA, mitochondria. These ar ...

. This family belongs to Mitochondrial clan ''CYP''s, which is located in the inner membrane of

mitochondria A mitochondrion () is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi. Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is us ...

(IMM). There are three members in the human genome,

CYP27A1 CYP27A1 is a gene encoding a cytochrome P450 oxidase, and is commonly known as sterol 27-hydroxylase. This enzyme is located in many different tissues where it is found within the mitochondria. It is most prominently involved in the biosynthesi ...

CYP27B1 25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the ''CYP27B1'' gene. ...

and

CYP27C1 CYP27C1 (cytochrome P450, family 27, subfamily C, polypeptide 1) is a protein that in humans is encoded by the ''CYP27C1'' gene. The Enzyme Commission number (EC) for this protein is EC 1.14.19.53. The full accepted name is ''all-trans-''retinol ...

, and an ortholog CYP27F1 in

sea urchins Sea urchins or urchins () are echinoderms in the class Echinoidea. About 950 species live on the seabed, inhabiting all oceans and depth zones from the intertidal zone to deep seas of . They typically have a globular body covered by a spiny p ...

, ''

Strongylocentrotus purpuratus ''Strongylocentrotus purpuratus'' is a species of sea urchin in the family Strongylocentrotidae commonly known as the purple sea urchin. It lives along the eastern edge of the Pacific Ocean extending from Ensenada, Mexico, to British Columbi ...

''.

References

Cytochrome P450 {{genetics-stub