CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''CXXC1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Proteins that contain a CXXC motif within their
DNA-binding domain
A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA. A DBD can recognize a specific DNA sequence (a recognition sequence) or have a gener ...
, such as CXXC1, recognize
CpG sequences and regulate
gene expression
Gene expression is the process (including its Regulation of gene expression, regulation) by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, ...
.
See also
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PHD finger
The PHD finger was discovered in 1993 as a Cysteine, Cys4-Histidine, His-Cys3 motif in the plant homeodomain (hence PHD) proteins HAT3.1 in ''Arabidopsis'' and maize ZmHox1a.
The PHD zinc finger motif resembles the metal binding RING domain (Cys ...
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CXXC5
References
External links
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Further reading
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