CUMYL-PINACA (also known as SGT-24) is an indazole-3-carboxamide based

synthetic cannabinoid Synthetic cannabinoids, or neocannabinoids, are a class of designer drug molecules that Binding affinity, bind to the same receptors to which cannabinoids (Tetrahydrocannabinol, THC, Cannabidiol, CBD and many others) in cannabis plants attach. Th ...

. CUMYL-PINACA acts as a potent

agonist An agonist is a chemical that activates a Receptor (biochemistry), receptor to produce a biological response. Receptors are Cell (biology), cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an R ...

for the

cannabinoid receptor Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system of vertebrates a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cann ...

s, with approximately 3x selectivity for CB₁, having an EC₅₀ of 0.15nM for human CB₁ receptors and 0.41nM for human CB₂ receptors. In its pure form, it is described as a sticky oil which can cause poisoning through

transdermal Transdermal is a route of administration wherein active ingredients are delivered across the skin for systemic distribution. Examples include transdermal patches used for medicine delivery. The drug is administered in the form of a patch or ointm ...

exposure.

Legal status

Sweden's public health agency suggested classifying CUMYL-PINACA as a hazardous substance, on November 10, 2014.

References

Cannabinoids Designer drugs Indazolecarboxamides {{cannabinoid-stub

Legal status

See also

References