The Cardiff University Brain Research Imaging Centre (CUBRIC) is a brain imaging centre, part of

Cardiff University Cardiff University () is a public research university in Cardiff, Wales. It was established in 1883 as the University College of South Wales and Monmouthshire and became a founding college of the University of Wales in 1893. It was renamed Unive ...

's Science and Innovation Campus in

Cardiff Cardiff (; ) is the capital city, capital and List of urban areas in the United Kingdom, largest city of Wales. Cardiff had a population of in and forms a Principal areas of Wales, principal area officially known as the City and County of Ca ...

Wales Wales ( ) is a Countries of the United Kingdom, country that is part of the United Kingdom. It is bordered by the Irish Sea to the north and west, England to the England–Wales border, east, the Bristol Channel to the south, and the Celtic ...

, United Kingdom. When it expanded in 2016, it was considered the most advanced brain imaging centre in Europe.

Building

Construction

CUBRIC was established in the

Cathays Park Cathays Park () or Cardiff Civic Centre is a civic centre area in the Cardiff City Centre, city centre of Cardiff, the capital city of Wales, consisting of a number of early 20th century buildings and a central park area, Alexandra Gardens. It ...

campus of Cardiff University in 2006, and moved to a new building in the Maindy Park campus in June 2016. The new building was constructed on old railway land, with the railway aiding in the delivery of the larger scanners. It cost £44,000,000, partially funded by Cardiff University, and partially by the

Welsh Government The Welsh Government ( ) is the Executive (government), executive arm of the Welsh devolution, devolved government of Wales. The government consists of Cabinet secretary, cabinet secretaries and Minister of State, ministers. It is led by the F ...

. It was officially opened by

Queen Elizabeth II Elizabeth II (Elizabeth Alexandra Mary; 21 April 19268 September 2022) was Queen of the United Kingdom and other Commonwealth realms from 6 February 1952 until Death and state funeral of Elizabeth II, her death in 2022. ...

on 7 June 2016.

Awards

The new building was awarded the title of Life Science Research Building 2017 by the UK Science Park Association. It also received the "Project of the Year" and "Design Through Innovation" awards from the

Royal Institution of Chartered Surveyors The Royal Institution of Chartered Surveyors (RICS) is a global professional body for those working in the Built Environment, Construction, Land, Property and Real Estate. The RICS was founded in London in 1868. It works at a cross-governmental ...

, who praised it for its "precise and beautifully detailed multi-sensory design". It was also a contender for the

National Eisteddfod of Wales The National Eisteddfod of Wales ( Welsh: ') is the largest of several eisteddfodau that are held annually, mostly in Wales. Its eight days of competitions and performances are considered the largest music and poetry festival in Europe. Competito ...

Gold Medal for Architecture in 2017. It has been designed to create a relaxing environment volunteers, with large windows and timber structures.

Research

Cardiff University's School of Psychology created CUBRIC to facilitate interdisciplinary brain research, using multiple

neuroimaging Neuroimaging is the use of quantitative (computational) techniques to study the neuroanatomy, structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive ...

machines and laboratory techniques. The centre houses: * 4 machines for

magnetic resonance imaging Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to generate pictures of the anatomy and the physiological processes inside the body. MRI scanners use strong magnetic fields, magnetic field gradients, and ...

(MRI) *

magnetoencephalography Magnetoencephalography (MEG) is a functional neuroimaging technique for mapping brain activity by recording magnetic fields produced by electric current, electrical currents occurring naturally in the human brain, brain, using very sensitive magn ...

(MEG) *

electroencephalography Electroencephalography (EEG) is a method to record an electrogram of the spontaneous electrical activity of the brain. The biosignal, bio signals detected by EEG have been shown to represent the postsynaptic potentials of pyramidal neurons in ...

(EEG) research * 5

electrical brain stimulation Electrical brain stimulation (EBS), also referred to as focal brain stimulation (FBS), is a form of electrotherapy and neurotherapy used as a technique in research and clinical neurobiology to stimulate a neuron or neural network in the brain ...

(EBS) laboratories * 10 cognitive method laboratories * the first

connectome A connectome () is a comprehensive map of neural connections in the brain, and may be thought of as its " wiring diagram". These maps are available in varying levels of detail. A functional connectome shows connections between various brain ...

scanner outside the

United States The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 ...

, a Siemens 3 Tesla Connectom system. A range of

cognitive neuroscience Cognitive neuroscience is the scientific field that is concerned with the study of the Biology, biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the brain which are involved in mental ...

studies are being carried out at CUBRIC, covering areas such as sleep research and curiosity research. The centre aims to investigate neurological aspects of conditions such as

epilepsy Epilepsy is a group of Non-communicable disease, non-communicable Neurological disorder, neurological disorders characterized by a tendency for recurrent, unprovoked Seizure, seizures. A seizure is a sudden burst of abnormal electrical activit ...

Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As the disease advances, symptoms can include problems wit ...

schizophrenia Schizophrenia () is a mental disorder characterized variously by hallucinations (typically, Auditory hallucination#Schizophrenia, hearing voices), delusions, thought disorder, disorganized thinking and behavior, and Reduced affect display, f ...

multiple sclerosis Multiple sclerosis (MS) is an autoimmune disease resulting in damage to myelinthe insulating covers of nerve cellsin the brain and spinal cord. As a demyelinating disease, MS disrupts the nervous system's ability to Action potential, transmit ...

, and

dementia Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform activities of daily living, everyday activities. This typically invo ...

. One of the centre's first major research projects in the new building involved the study of

Huntington's disease Huntington's disease (HD), also known as Huntington's chorea, is an incurable neurodegenerative disease that is mostly Genetic disorder#Autosomal dominant, inherited. It typically presents as a triad of progressive psychiatric, cognitive, and ...

. The connectome scanner generates a map of the

axon An axon (from Greek ἄξων ''áxōn'', axis) or nerve fiber (or nerve fibre: see American and British English spelling differences#-re, -er, spelling differences) is a long, slender cellular extensions, projection of a nerve cell, or neuron, ...

s in

white matter White matter refers to areas of the central nervous system that are mainly made up of myelinated axons, also called Nerve tract, tracts. Long thought to be passive tissue, white matter affects learning and brain functions, modulating the distr ...

, connections of the brain, by measuring the nearby movement of water molecules to precision. Anomalous structures and changes to the brain's function, called

biomarker In biomedical contexts, a biomarker, or biological marker, is a measurable indicator of some biological state or condition. Biomarkers are often measured and evaluated using blood, urine, or soft tissues to examine normal biological processes, ...

s, can be identified through comparison to scans of healthy brains.

References

External links

*
Tour of CUBRIC Building

Simple Explanation of Connectome Scanning

Delivery of 7T MRI Scanner
{{Cardiff University Cardiff University Magnetoencephalography Medical imaging in the United Kingdom Medical imaging research institutes Medical research institutes in the United Kingdom Neuroimaging Neuroscience research centres in the United Kingdom