CTW0415 is an experimental drug from the

piperidine Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene bridges (–CH2–) and one amine bridge (–NH–). It is a colorless liquid with an odor de ...

family, which acts as a selective positive

allosteric modulator In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimuli. Some of them, like benzodiazepines or alcohol, function as psychoactive drugs. The site that a ...

of the 5-HT_2C

receptor Receptor may refer to: * Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and respond ...

, with higher potency than older drugs such as

VA012 VA012 is an experimental drug from the indole family, which is acts as a selective positive allosteric modulator of the 5-HT2C receptor. It has anorectic effects in animal studies with an improved side effect profile compared to directly acting ...

. Structure-activity relationship studies showed that small variations to chain length and side chain substitution could lead to preferential binding for either 5-HT_2C or the related 5-HT_2A receptor, which subsequently led to the discovery of the related 5-HT_2A selective positive allosteric modulator

CTW0404 CTW0404 is an experimental drug which is described as a positive allosteric modulator of the 5-HT2A receptor, with neutral or negative modulation of the related 5-HT2B and 5-HT2C subtypes. It does not produce the head-twitch response The head ...

References

5-HT2C receptor positive allosteric modulators Amides Phenyl compounds Piperidines Diols {{nervous-system-drug-stub