CPP-115 is an experimental drug being studied for the treatment of various neurological and psychiatric disorders including cocaine addiction, infantile spasms, and

Tourette syndrome Tourette syndrome or Tourette's syndrome (abbreviated as TS or Tourette's) is a common neurodevelopmental disorder that begins in childhood or adolescence. It is characterized by multiple movement (motor) tics and at least one vocal (phonic) ...

. CPP-115 is a

GABA aminotransferase GABA aminotransferase may refer to: * 4-aminobutyrate—pyruvate transaminase 4-aminobutyrate---pyruvate transaminase (, ''aminobutyrate aminotransferase'', ''gamma-aminobutyrate aminotransaminase'', ''gamma-aminobutyrate transaminase'', ''gamma-am ...

(GABA-AT) inactivator.

History

CPP-115 was discovered in the research laboratory of Richard B. Silverman, for which he received the E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances. It was licensed to

Catalyst Pharmaceuticals Catalyst Pharmaceuticals Inc. is a biopharmaceutical company based in Coral Gables, Florida. The company is developing medicines for rare diseases, including the phosphate salt of amifampridine for the treatment of Lambert–Eaton myasthenic synd ...

for

development Development or developing may refer to: Arts *Development hell, when a project is stuck in development *Filmmaking, development phase, including finance and budgeting *Development (music), the process thematic material is reshaped *Photographi ...

in 2009. CPP-115 has been granted

orphan drug An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without government assistance. The conditions are referred to as orphan diseases. The assignment o ...

status for the treatment of infantile spasms by the FDA and for the treatment of

West syndrome Epileptic spasms is an uncommon-to-rare epileptic disorder in infants, children and adults. One of the other names of the disorder, West syndrome, is in memory of the English physician, William James West (1793–1848), who first described it in ...

by the European Commission. As of 2022, CPP-115 is in

Phase II clinical trials The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases ...

for Tourette syndrome.

References

Gamma-Amino acids Cyclopentanes Organofluorides {{nervous-system-drug-stub