Coronin, actin binding protein, 1B also known as CORO1B is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
which in humans is encoded by the ''CORO1B''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Members of the
coronin family, such as CORO1B, are
WD repeat
The WD40 repeat (also known as the WD or beta-transducin repeat) is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Tandem copies of these repeats typically fold togethe ...
-containing
actin
Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils. It is found in essentially all eukaryotic cells, where it may be present at a concentration of ...
-binding proteins that regulate
cell motility
Motility is the ability of an organism to move independently using metabolism, metabolic energy. This biological concept encompasses movement at various levels, from whole organisms to cells and subcellular components.
Motility is observed in ...
.
Function
A mammalian
coronin enriches at the leading edge of migrating cells.
Studies related to this protein are as follows:
* Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.
* F-actin binding is essential for coronin 1B function in vivo.
* Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
* Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
* In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.
* Isolation, cloning, and characterization of a new mammalian coronin family member, , which is regulated within the protein kinase C signaling pathway.
References
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