COPP is a
chemotherapy regimen
A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations. In modern oncology, many regimens combine several chemotherapy drugs in combi ...
for treatment of
Hodgkin lymphoma
Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cell called lymphocytes, where multinucleated Reed–Sternberg cells (RS cells) are present in the lymph nodes. The condition was named a ...
, consisting of concurrent treatment with
Cyclophosphamide,
Oncovin,
Procarbazine and
Prednisone.
Compared with the similar
MOPP regimen for both pediatric and adult cases,
COPP uses less procarbazine (it is given only for 10 days in cycle instead of 14), and it replaces the very toxic
mechlorethamine with cyclophosphamide, which is safer for progenitor stem cells (and hence less prone to causing severe
neutropenia
Neutropenia is an abnormally low concentration of neutrophils (a type of white blood cell) in the blood. Neutrophils make up the majority of circulating white blood cells and serve as the primary defense against infections by destroying bacteria ...
) and carries a lower risk of secondary malignancies.
Thus the COPP regimen is considered safer and less toxic than MOPP. But the benefits are offset by its lower efficacy, especially in advanced-stage Hodgkin lymphoma.
Nevertheless, both the COPP and the MOPP are now supplanted by
ABVD, which is less toxic and more effective than either COPP or MOPP.
Dosage
References
{{DEFAULTSORT:Copp
Chemotherapy regimens used in lymphoma