Conserved oligomeric Golgi complex subunit 7 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''COG7''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Multiprotein complexes are key determinants of
Golgi apparatus
The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic Cell (biology), cells. Part of the endomembrane system in the cytoplasm, it protein targeting, packages proteins ...
structure and its capacity for
intracellular transport
Intracellular transport is the movement of Vesicle (biology and chemistry), vesicles and substances within a Cell (biology), cell. Intracellular transport is required for maintaining homeostasis within the cell by responding to physiological sign ...
and glycoprotein modification. Several complexes have been identified, including the
Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the
conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).
upplied by OMIMref name="entrez"/>
Interactions
COG7 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
COG4 and
COG5.
[
]
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
External links
GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
*
{{gene-16-stub