Calcineurin B homologous protein 1 is a protein encoded in humans by the ''CHP1''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
(formerly ''CHP'').
Function
The protein encoded by this gene is a
phosphoprotein
A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonin ...
that binds to the sodium-hydrogen exchangers (NHEs). This protein serves as an essential
cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of
calcineurin
Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase 3, and calcium-dependent serine-threonine phosphatase). It activates the T cells of the immune system and can be block ...
activity.
Interactions
Calcineurin B homologous protein 1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with
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sodium-hydrogen antiporter 1,
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sodium-hydrogen antiporter 3,
[ and
* sodium-hydrogen anti porter 9.]
References
Further reading
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External links
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{{gene-15-stub
EF-hand-containing proteins