Centrosomal protein of 68 kDa is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

that in humans is encoded by the ''CEP68''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. CEP68 is required for

centrosome In cell biology, the centrosome (Latin centrum 'center' + Greek sōma 'body') (archaically cytocentre) is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell, as well as a regulator of cell-cycle pro ...

cohesion. It decorates fibres emanating from the proximal ends of

centriole In cell biology a centriole is a cylindrical organelle composed mainly of a protein called tubulin. Centrioles are found in most eukaryotic cells, but are not present in conifers ( Pinophyta), flowering plants ( angiosperms) and most fungi, a ...

s. During mitosis, CEP68 dissociates from centrosomes. CEP68 and

rootletin Rootletin also known as ciliary rootlet coiled-coil protein (CROCC) is a protein that in humans is encoded by the ''CROCC'' gene. Rootletin is a component of the ciliary rootlet, and, together with CEP68 and CEP250, is required for centrosome co ...

depend both on each other for centriole association, and both also require

CEP250 Centrosome-associated protein CEP250 is a protein that in humans is encoded by the ''CEP250'' gene. This gene encodes a core centrosome, centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded ...

for their function.

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