Cadherin EGF LAG seven-pass G-type receptor 2 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

that in humans is encoded by the ''CELSR2''

gene In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...

. The protein encoded by this gene is a member of the

flamingo subfamily Flamingos or flamingoes are a type of wading bird in the family Phoenicopteridae, which is the only extant family in the order Phoenicopteriformes. There are four flamingo species distributed throughout the Americas (including the Caribbean ...

, part of the

cadherin superfamily Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to allow cells to adhere to each other . Cadherins are a class of type-1 transmembrane proteins ...

. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with

catenin Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bi ...

s. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as

homophilic Terms used to describe homosexuality have gone through many changes since the emergence of the first terms in the mid-19th century. In English, some terms in widespread use have been sodomite, Achillean, Sapphic, Uranian, homophile, lesbian, ...

binding regions and the EGF-like domains involved in

cell adhesion Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. This process can occur either through direct contact between cell surfaces such as cell junctions or indir ...

and receptor-ligand interactions. The specific function of this particular member has not been determined.

References

External links

* Adhesion G protein-coupled receptors G protein-coupled receptors {{transmembranereceptor-stub

See also

References

Further reading

External links