CD3e molecule, epsilon also known as CD3E is a
polypeptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides.
A p ...
which in humans is encoded by the ''CD3E''
gene which resides on chromosome 11.
Function
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-
gamma
Gamma (uppercase , lowercase ; ''gámma'') is the third letter of the Greek alphabet. In the system of Greek numerals it has a value of 3. In Ancient Greek, the letter gamma represented a voiced velar stop . In Modern Greek, this letter re ...
, -
delta and -
zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the
T cell receptor-
CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.
Clinical significance
Defects in this gene cause severe
immunodeficiency
Immunodeficiency, also known as immunocompromisation, is a state in which the immune system's ability to fight infectious diseases and cancer is compromised or entirely absent. Most cases are acquired ("secondary") due to extrinsic factors that a ...
.
This gene has also been linked to a susceptibility to type I diabetes in women.
Interactions
T-cell surface glycoprotein CD3 epsilon chain has been shown to
interact with
TOP2B,
and
NCK2.
See also
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CD3 (immunology)
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Cluster of differentiation
References
Further reading
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{{NLM content
Clusters of differentiation