CD2-associated protein is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''CD2AP''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites,
SH3 domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of ph ...
s, and a
proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to
membrane ruffles,
lipid raft
The cell membrane, plasma membranes of cells contain combinations of glycosphingolipids, cholesterol and protein Receptor (biochemistry), receptors organized in glycolipoprotein lipid microdomains termed lipid rafts. Their existence in cellular me ...
s, and the leading edges of cells. It is implicated in dynamic
actin remodeling
Actin is a protein family, family of Globular protein, globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in myofibril, muscle fibrils. It is found in essentially all Eukaryote, eukaryotic cel ...
and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
Interactions
CD2AP has been shown to
interact with:
*
Cbl gene,
*
NPHS2
Podocin is a protein that in humans is encoded by the ''NPHS2'' gene.
Interactions
NPHS2 has been shown to Protein-protein interaction, interact with Nephrin and CD2AP.
See also
* Focal segmental glomerulosclerosis
References
Further ...
,
*
Nephrin,
and
*
RAB4A
Ras-related protein Rab-4A is a protein that in humans is encoded by the ''RAB4A'' gene.
Interactions
RAB4A has been shown to interact with:
* CD2AP,
* KIF3B,
* RAB11FIP1,
* RABEP1, and
* STX4
Syntaxin-4 is a protein that in humans ...
.
[
]
See also
* Focal segmental glomerulosclerosis
References
Further reading
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External links
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{{gene-6-stub