C-X-C chemokine receptor type 6 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metab ...
that in humans is encoded by the ''CXCR6''
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
CXCR6 has also recently been designated CD186 (
cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophe ...
186).
CXCR6 has been identified as an entry coreceptor used by HIV-1 and SIV to enter target cells, in conjunction with CD4.
It is a minor coreceptor for HIV-1, nearly all strains of which use CCR5 and/or CXCR4. Most SIV strains can use CXCR6 and recent evidence suggests that in monkeys that serve as the natural hosts of SIV, CXCR6 may be a major coreceptor.
CXCR6 was previously known as "Bonzo" and "STRL33" in the HIV/SIV field.
References
Further reading
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External links
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Clusters of differentiation
Chemokine receptors
{{transmembranereceptor-stub