Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the
Interleukin-5 receptor
The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB.
The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of tw ...
. IL5RA also denotes its human
gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei ...
.
Function
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (
syntenin), which is required for IL5 mediated activation of the transcription factor
SOX4
Transcription factor SOX-4 is a protein that in humans is encoded by the ''SOX4'' gene.
Function
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic dev ...
. Six alternatively spliced transcript variants encoding three distinct
isoforms
A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene and are the result of genetic differences. While many perform the same or similar biological roles, some isoforms have uniqu ...
have been reported.
Interactions
Interleukin 5 receptor alpha subunit has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization advocating for the legal and human rights of children with intersex traits. The organization was founded in 2006 and fo ...
with:
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Interleukin 5
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells.
Function
Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion—primarily I ...
,
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Janus kinase 2
Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CS ...
,
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Protein unc-119 homolog
Uncoordinated-119 (Unc-119) is a protein identified in a varieties of species including, ''C. elegans'', humans, mice, zebrafish, rabbits, pig, calf, monkey, and protozoa. This proteins have been classified in the GMP phosphodiesterase, delta supe ...
,
and
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SDCBP
Syntenin-1 is a protein that in humans is encoded by the ''SDCBP'' gene.
Function
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains t ...
See also
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophe ...
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Benralizumab
Benralizumab, sold under the brand name Fasenra, is a monoclonal antibody directed against the alpha chain of the interleukin-5 receptor ( CD125). It was developed by MedImmune for the treatment of asthma. It is currently marketed by Astrazen ...
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Mepolizumab
Mepolizumab, sold under the brand name Nucala by GlaxoSmithKline, is a humanized monoclonal antibody used for the treatment of severe eosinophilic asthma, eosinophilic granulomatosis with polyangiitis, and hypereosinophilic syndrome (HES). It r ...
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Reslizumab
Reslizumab, sold under the brand names Cinqair and Cinqaero, is a humanized monoclonal antibody against human Interleukin 5, interleukin-5 (IL-5). Reslizumab binds specifically to IL-5, a key cytokine responsible for the differentiation, maturati ...
References
Further reading
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External links
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{{Interleukin receptor modulators
Clusters of differentiation